E-ISSN: 1309-0380
    Utility of preoperative neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios to distinguish malignant from benign ovarian masses
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    Original Investigation
    VOLUME: 17 ISSUE: 1
    P: 21-25
    March 2016

    Utility of preoperative neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios to distinguish malignant from benign ovarian masses

    J Turk Ger Gynecol Assoc 2016;17(1):21-25
    DOI: 10.5152/jtgga.2015.0152
    Murat Bakacak 1
    Salih Serin 2
    Önder Ercan 1
    Bülent Köstü 1
    Mehmet Sühha Bostancı 2
    Zeyneb Bakacak 3
    Hakan Kıran 1
    Gürkan Kıran 1
    1. Department of Obstetrics and Gynecology, Kahramanmaraş Sütçü İmam University School of Medicine, Kahramanmaraş, Turkey
    2. Clinic of Obstetrics and Gynecology, Sakarya University Training and Research Hospital, Sakarya, Turkey
    3. 3Clinic of Obstetrics and Gynecology, Private Caka Vatan Hospital, Kahramanmaraş, Turkey
    No information available.
    No information available
    Received Date: 06.08.2015
    Accepted Date: 28.11.2015
    Publish Date: 28.11.2017
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    ABSTRACT

    Objective:

    We aimed to investigate the utility of preoperative neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte count as biomarkers to distinguish malignant from benign ovarian masses.

    Material and Methods:

    We retrospectively reviewed the histopathological results of 185 benign and 33 malignant cases following surgery for an initial diagnosis of adnexal mass and confirmed ovarian masses. Age, cancer antigen 125 (CA-125), white blood cell (WBC) count, hemoglobin (Hb), hematocrit (Hct), mean platelet volume (MPV), platelet distribution width (PDW), NLR, PLR, and lymphocyte counts were compared between groups.

    Results:

    The significant diagnostic factors to distinguish malignant from benign disease were age (35.5±22 vs. 62±13 years; p<0.001) and CA-125 levels (16.6±21 vs. 98±366 U/mL; p<0.001). No significant difference was observed in WBC count, Hct, Hb, platelet count, PDW, and MPV between groups. To distinguish malignant from benign masses, lymphocyte count (1.29±0.91 vs. 1.80±0.67×103 cells/µL, p<0.001), NLR (4.95±5.36 vs. 3.32±2.72, p=0.024), and PLR (203.41±107.84 vs. 160.75±70.84, p<0.001) were identified as markers. The cutoff values were lymphocyte count of >1500 cells/µL (p<0.001), NLR of 3.4732 (p=0.033), PLR of 161.13 (p<0.001), CA-125 of >40 U/mL (p<0.001), and age of >53 years (p<0.001); their respective sensitivity and specificity were 66.7% and 77.8% [area under the curve (AUC), 0.723±0.055], 68.8% and 54.1% (AUC, 0.624±0.058), 81.8% and 50.8% (AUC, 0.683±0.052), 78.8% and 77.8% (AUC, 0.797±0.057), and 81.8% and 82.2% (AUC, 0.888±0.025). Multiple logistic regression analysis revealed cutoff explanatory and accuracy values of 68.2% and 94.9%, respectively, for lymphocyte count, NLR, PLR, CA-125, and age as independent parameters to distinguish malignant from benign ovarian masses.

    Conclusion:

    In combination with age and CA-125 levels, NLR, PLR, and lymphocyte count may be helpful to preoperatively distinguish malignant from benign ovarian masses.

    Keywords: Neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, malignant ovarian mass, benign ovarian mass

    References

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