E-ISSN: 1309-0380
    Uterine artery catheterization and selective embolization for leiomyoma: Patient acceptance and clinical outcome
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    Clinical Study
    VOLUME: 8 ISSUE: 2
    P: 203-207
    June 2007

    Uterine artery catheterization and selective embolization for leiomyoma: Patient acceptance and clinical outcome

    J Turk Ger Gynecol Assoc 2007;8(2):203-207
    Sahin Zeteroglu 1
    Eray Çaliskan 2
    Mustafa Harman 3
    Muzaffer Sengül 4
    Ebru Coskun 5
    Bülent Tiras 6
    Mansur Kamaci 7
    1. Department Of Obstetrics And Gynecology, Mustafa Kemal University Faculty Of Medicine, Hatay, Turkey
    2. Department Of Obstetrics And Gynecology, Faculty Of Medicine, Kocaeli University, Kocaeli, Turkey
    3. Department Of Radiodiagnostics, Faculty Of Medicine, Ege University, Izmir, Turkey
    4. Universale Hospital, Obstetrics And Gynecology Clinic, Adana, Turkey
    5. Department Of Obstetrics And Gynecology, Kocaeli University Faculty Of Medicine, Kocaeli, Turkey
    6. Department Of Obstetrics And Gynecology, Faculty Of Medicine, Gazi University, Ankara, Turkey
    7. Department Of Obstetrics And Gynecology, Faculty Of Medicine, Yu¨Zu¨Ncu¨ Yil University, Van, Turkey
    No information available.
    No information available
    Received Date: 09.05.2006
    Accepted Date: 21.03.2007
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    ABSTRACT

    OBJECTIVE:

    To evaluate the patient acceptance and clinical outcome after selective uterine leiomyoma embolisation.

    MATERIAL-METHODS:

    Twenty-four women with symptomatic uterine fibroid were recruited for this study. Selective uterine leiomyoma embolisation proceeded until complete vascular occlusion was achieved. The main outcome measure was decrease in the leiomyoma volume and factors that predict it. Pearson correlation analysis and lineer regression analysis were performed to identify possible correlates and predictors of decrease in leiomyoma volume. Patient satisfaction was assessed by asking the subjects to indicate their degree of satisfaction on a five-point scale.

    RESULTS:

    The mean age of the patients was 41.5±4.9 (Range: 28-52). The mean leiomyoma volume before the procedure was 157 ± 214 cm3 which was calculated to be 44 ± 66cm3 with a 76 ± 17 % (Range= 30-99%) decrease in the mean leiomyoma volume at the end of one year. Correlation analysis revealed that only preoperative estradiol level was positively correlated to the extent of decrease in the leiomyoma volume (r=0.54, p=0.005). This was also proved in the regression analysis (beta=0.25, p=0.01). During the follow-up 17 (70.8%) patients had complete remission of the symptoms, five (20.8%) had partial remission and two (8.3%) had no clinically significant change. Twenty patients (83.3%) were completely satisfied, two were satisfied and two were dissatisfied with the leiomyoma embolisation procedure.

    CONCLUSION:

    There is a positive correlation between the preoperative estradiol level and the extent of the decrease in the leiomyoma volume after the embolisation procedure. As leiomyoma is a hormone dependent tumor, the shrinkage of the leiomyoma seems also dependent on the estradiol levels before the precedure besides the ischemic necrosis caused secondary to arterial embolisation.

    Keywords: Leiomyoma, arterial embolization, clinical outcome, estradiol level

    References

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