E-ISSN: 1309-0380
    The role of TWIST, SERPINB5, and SERPIN1 genes in uterine leiomyomas
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    Original Investigation
    VOLUME: 15 ISSUE: 2
    P: 92-95
    June 2014

    The role of TWIST, SERPINB5, and SERPIN1 genes in uterine leiomyomas

    J Turk Ger Gynecol Assoc 2014;15(2):92-95
    DOI: 10.5152/jtgga.2014.13005
    Mehmet Sühha Bostancı 1
    Merih Bayram 2
    Süleyman Murat Bakacak 3
    Özge Kızılkale Yıldırım 4
    Rukset Attar 4
    Gazi Yıldırım 4
    Emin Ümit Bagrıaçık 5
    Baran Celtemen 6
    1. Department Of Obstetrics And Gynecology, Sakarya University Faculty Of Medicine, Sakarya, Turkey
    2. Department Of Obstetrics And Gynecology, Kirikkale University Faculty Of Medicine, Kirikkale, Turkey
    3. Department Of Obstetrics And Gynecology, Sütçü Imam University Faculty F Medicine, Kahramanmaras, Turkey
    4. Department Of Obstetrics And Gynecology, Yeditepe University Faculty Of Medicine, Istanbul, Turkey
    5. Department Of Immunology, Gazi University Faculty Of Medicine, Ankara, Turkey
    6. Department Of Obstetrics And Gynecology, Gazi University Faculty Of Medicine, Ankara, Turkey
    No information available.
    No information available
    Received Date: 07.02.2014
    Accepted Date: 07.05.2014
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    ABSTRACT

    Objective:

    The aim of this study is investigate the role of the Twist homolog 1 (TWIST), serine peptidase inhibitor (SERPINB5), and plasminogen activator inhibitor 1 (SERPIN1) genes in uterine leiomyoma etiopathogenesis.

    Material and Methods:

    Twelve patients, aged between 39 and 58, and had a hysterectomy, were included in the study. The size of the leiomyomas was between 20 and 130 mm based on gross pathology after hysterectomy. Tissue samples were obtained from normal myometrium and leiomyoma (1 cm³) tissue of the uterus of the patients and stored at -86°C. Samples were divided to two groups after histopathological evaluation of the uterus: normal myometrial tissues as control group (Group 1) and leiomyoma tissue as the study group (Group 2). The TWIST, SERPINB5, and SERPIN1 genes were studied for uterine leiomyoma etiopathogenesis.

    Results:

    TWIST gene expression was significantly higher in the uterine leiomyoma tissue (p<0.001). SERPINB5 and SERPIN1 gene expression was decreased in the uterine leiomyoma tissue, but the differences were not statistically significant.

    Conclusion:

    TWIST gene activity is significantly increased in leiomyoma tissue when compared to normal myometrium. In spite of the fact that the development of uterine leiomyomas is estrogen- and progesterone-dependent, myometrial cells could be triggered by the TWIST gene for uterine leiomyoma development.

    Keywords: Uterine leiomyomas, etiopathogenesis

    References

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