ß-human chorionic gonadotropin assay in vaginal washing fluid for the accurate diagnosis of premature rupture of membranes during late pregnancy
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    Original Investigation
    P: 201-204
    December 2013

    ß-human chorionic gonadotropin assay in vaginal washing fluid for the accurate diagnosis of premature rupture of membranes during late pregnancy

    J Turk Ger Gynecol Assoc 2013;14(4):201-204
    1. Department Of Obstetrics And Gynecology, Zeynep Kamil Training And Research Hospital, Istanbul, Turkey
    2. Department Of Gynecology And Obstetrics, Zeynep Kamil Training And Research Hospital, Istanbul, Turkey
    3. Department Of Obstetrics And Gynecology, Zeynep Kamil Training And Education Hospital, Istanbul, Turkey
    No information available.
    No information available
    Received Date: 01.06.2013
    Accepted Date: 19.09.2013
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    ABSTRACT

    Objective:

    To determine whether the measurement of beta-human chorionic gonadotropin (β-hCG) levels in vaginal fluid is useful for the diagnosis of premature rupture of membranes (PROM).

    Material and Methods:

    A total of 92 pregnant women between 24 and 40 weeks gestation participated in this study. The patients with fluid leaking from the vagina were designated Group 1, the patients with no fluid leaking from the vagina were Group 2, and those with a suspicion of fluid leaking from the vagina were classified as Group 3. Irrigating the posterior vaginal fornix with 5 mL sterile saline was used to measure β-hCG levels of the patients. Receiver operator curve (ROC) analysis was used to determine the cut-off value for a positive diagnosis.

    Results:

    The β-hCG levels of vaginal fluid were measured as 20.5±25.0 mIU/mL, 254.6±346.8 mIU/mL, and 74.3±100.8 mIU/mL in Group 1, Group 2, and Group 3, respectively. Vaginal β-hCG level was higher statistically significantly in Group 2 than Group 1 and 3 (p)

    Conclusion:

    The study showed that the measurement of β-hCG level in vaginal washing fluid is an efficient and easy diagnostic test for predicting the amount of fluid leaking from the vagina. However, due to the low negative predictive value of the test, it would not be convenient in daily practice.

    Keywords: Beta-human chorionic gonadotropin, premature rupture of membranes, diagnosis

    References

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