Melatonin Treatment Results in Regression of Endometriotic Lesions in An Ooferectomized Rat Endometriosis Model

J Turk Ger Gynecol Assoc 2013;14(2):81-86

1. Yeditepe University Hospital, Department Of Obstetrics And Gynecology, Istanbul, Turkey

2. Center For Reproductive Medicine, Department Of Obstetrics And Gynecology, Yeditepe University Hospital, Istanbul, Turkey

3. Department Of Gynecology And Obstetrics Medical Faculty, Yeditepe University, Istanbul, Turkey

4. Yeditepe University Hospital, Center For Reproductive Medicine, Head Of The Department Of Obstetrics, And Gynecology, Istanbul, Turkey

5. Yeditepe University Hospital, Department Of Pathology, Istanbul, Turkey

6. Department Of Physiology And Experimental Studies And Research Center, Yeditepe University School Of Medicine, Istanbul, Turkey

7. Department Of Obstetrics And Gynecology, Yeditepe University School Of Medicine, Istanbul, Turkey

No information available.

No information available

Received Date: 15.04.2013

Accepted Date: 24.04.2013

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ABSTRACT

Objective:

We aimed to determine the effects of melatonin treatment on endometrial implants in an oopherectomized rat endometriosis model.

Material and Methods:

This study is a prospective, randomised, controlled experimental study. It was carried out at the Experimental Research Center of Yeditepe University (YUDETAM). Twenty-two, female, non-pregnant, nulligravid Spraque-Dawley albino rats were included in our study. Endometriosis was surgically induced in oopherectomized rats. Rats were randomised into two groups: control group and melatonin group. In the melatonin group, rats were treated with melatonin (20 mg/kg/day) for two weeks. After the operations were performed to assess the regression of the endometriotic lesions, melatonin treatment was stopped. At the end of the sixth week necropsies were performed to assess the rate of recurrence. The volume and histopathological scores of endometriotic foci were examined.

Results:

Volumes of the endometriotic lesions significantly decreased in the melatonin group. Also, when the melatonin group was analysed within itself, endometriotic lesion volumes decreased and histopathological scores increased significantly.

Conclusion:

Melatonin causes regression of the endometriotic lesions in rats and improvement in their histopathological scores.

Keywords: Endometriosis, oopherectomized rats, volume, histopathological score, melatonin

Melatonin Treatment Results in Regression of Endometriotic Lesions in An Ooferectomized Rat Endometriosis Model

ABSTRACT

References