E-ISSN: 1309-0380
    Improvement in embryo quality and pregnancy rates by using autologous cumulus body during icsi cycles
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    Original Investigation
    VOLUME: 12 ISSUE: 3
    P: 162-167
    September 2011

    Improvement in embryo quality and pregnancy rates by using autologous cumulus body during icsi cycles

    J Turk Ger Gynecol Assoc 2011;12(3):162-167
    DOI: 10.5152/jtgga.2011.38
    Tahsin Murad Aktan 1
    Hüzeyin Görkemli 2
    Kazım Gezginç 3
    Aslı Saylan 1
    Selçuk Duman 4
    Fatma Yazıcı Yılmaz 5
    1. Department Of Histology And Embryology, Meram Faculty Of Medicine, Selçuk University, Konya, Turkey
    2. Department Of Obstetrics And Gynecology, Meram Medical Faculty, Selcuk University, Konya, Turkey
    3. Department Of Obstetrics And Gynecology, Selçuk University Faculty Of Medicine, Konya, Turkey
    4. Department Of Histology And Embryolog, Meram Medical Faculty, Selcuk University, Konya, Turkey
    5. Department Of Obstetrics And Gynecology, Meram Faculty Of Medicine, Selçuk University, Konya, Turkey
    No information available.
    No information available
    Received Date: 03.07.2011
    Accepted Date: 07.08.2011
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    ABSTRACT

    Objective:

    To determine whether the addition of intact cumulus cell mass (ICM) to both embryo culture (EC) and embryo transfer (ET) improves embryo quality and pregnancy rates.

    Material and Methods:

    A total of 133 infertile couples were included, of which 67 received ICM (study group) and 66 did not (control group). The ICM was obtained from a simple cutting of the cumulus corona oocyte complex (CCOC). A case control study design was used.

    Results:

    The clinical characteristics of the two groups before the embryo culturing step were similar with respect to age, estradiol level on the day of hCG and endometrial thickness on the day of embryo transfer (p>0.05). On the other hand study group with ICM had higher number of high quality embryos (3.1±1.4 vs 2.4±1.1, p=0.03), higher implantation rate (53.7% vs 34.8%, p=0.02) and higher ultrasound confirmation of gestational sac and fetal heart beat as ongoing pregnancy rates (44.7% vs 27.2%, p=0.04) compared to the control group without ICM.

    Conclusion:

    Addition of ICM improves embryo quality and pregnancy rates. This is a cost-and time-effective simple procedure that shows great promise for the improvement of infertility treatment.

    Keywords: Autologous Cumulus Body, ICSI Cycles, Embryo Quality, Pregnancy Rates

    References

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