E-ISSN: 1309-0380
    Glyceryl trinitrate for the treatment of preterm labor
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    Original Investigation
    VOLUME: 16 ISSUE: 3
    P: 174-178
    September 2015

    Glyceryl trinitrate for the treatment of preterm labor

    J Turk Ger Gynecol Assoc 2015;16(3):174-178
    DOI: 10.5152/jtgga.2015.15016
    Şafak Çalışkan 1
    Mehmet Ali Narin 2
    Faruk Suat Dede 3
    Raziye Narin 4
    Hülya Dede 5
    Ömer Kandemir 3
    1. Clinic Of Obstetrics And Gynecology, Nazilli State Hospital, Aydin, Turkey
    2. Department Of Obstetrics And Gynecology, Erzincan University Faculty Of Medicine, Erzincan, Turkey
    3. Clinic Of Obstetrics And Gynecology, Etlik Zübeyde Hanim Training And Research Hospital Ankara, Turkey
    4. Clinic Of Obstetrics And Gynecology, Numune Training And Research Hospital, Adana, Turkey
    5. Clinic Of Obstetrics And Gynecology, Zekai Tahir Burak Training And Research Hospital, Ankara, Turkey
    No information available.
    No information available
    Received Date: 28.02.2015
    Accepted Date: 24.03.2015
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    ABSTRACT

    Objective:

    This study was conducted to compare the tocolytic efficacy of glyceryltrinitrate (GTN) with that of magnesium sulfate (MgSO4) and to investigate serum nitric oxide metabolites before and after tocolysis.

    Material and Methods:

    In total, 48 women between 27 and 34 weeks’ gestation with threatened preterm labor and intact membranes were randomly allocated to receive either GTN or MgSO4 tocolysis. Main outcome measures included tocolytic efficacy and maternal side effect(s) of the tocolytic agent. Obstetric and neonatal outcomes as well as pretreatment and posttreatment nitric oxide (NO) metabolites were assessed.

    Results:

    Forty-one patients were included into the final analysis. Uterine contraction cessation times were 3.66±1.28 and 6.83±3.47 hours for GTN and MgSO4 groups, respectively. Similarly, maternal side effects were significantly lower in the GTN group than in the MgSO4 group, and no serious maternal side effects were recorded. Serum NO metabolite levels before treatment were significantly lower in the treatment groups than in the controls. Serum nitrite levels were significantly increased after tocolytic treatment both in MgSO4 and GTN groups.

    Conclusion:

    GTN effectively delays preterm delivery and reduces neonatal morbidity and mortality with less maternal side effects and seems to be an effective and safe alternative to MgSO4.

    Keywords: Glyceryl trinitrate, nitric oxide, magnesium sulfate, tocolysis

    References

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