Comparison of serum androgens and endometrial thickness in obese and non-obese postmenopausal women

J Turk Ger Gynecol Assoc 2010;11(3):149-151

DOI: 10.5152/jtgga.2010.23q

1. Department Of Obstetrics And Gynecology, Faculty Of Medicine, Zonguldak Karaelmas University, Zonguldak, Turkey

2. Department Of Gynecology And Obstetrics, Faculty Of Medicine, Kahramanmaras Su¨Tcu¨ Imam University, Kahramanmaras, Turkey

3. Department Of Obstetrics And Gynecology, Harran University Faculty Of Medicine, Sanliurfa, Turkey

4. Department Of Obstetrics And Gynecology, Maltepe University, Istanbul, Turkey

No information available.

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Received Date: 03.08.2010

Accepted Date: 13.11.2010

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ABSTRACT

Objective:

In this study, we investigated whether serum androgen levels and endometrial thickness differed in obese and non-obese women.

Material and Methods:

Thirtytwo non-obese (BMI <30) and 48 obese (BMI ≥ 30) women were enrolled. Blood samples were analyzed for testosterone, free testosterone, androstenedione, DHEAS, and SHBG, and transvaginal ultrasonography was performed.

Results:

Obese women had significantly higher free testosterone and endometrial thickness and significantly lower SHBG. Eight of 17 women with endometrial thickness >5 mm had significant pathology.

Conclusion:

These results suggest that obesity may be a risk factor for endometrial carcinoma and other pathologies in post-menopausal women through an action on androgen concentrations.

Keywords: Serum androgene, endometrial thickness, obesity, postmenopause

Comparison of serum androgens and endometrial thickness in obese and non-obese postmenopausal women

ABSTRACT

References