E-ISSN: 1309-0380
The relationship between first-trimester pregnancy-associated plasma protein-A levels and intrapartum fetal distress development
PDF
Cite
Share
Request
Original Investigation
VOLUME: 17 ISSUE: 3
P: 139-142
September 2016

The relationship between first-trimester pregnancy-associated plasma protein-A levels and intrapartum fetal distress development

J Turk Ger Gynecol Assoc 2016;17(3):139-142
DOI: 10.5152/jtgga.2016.16022
Ayşe Filiz Avşar 1
Elçin İşlek Seçen 2
Gülin Feykan Yeğin Akçay 2
Hüseyin Levent Keşkin 2
Emre Erdem Taş 1
Ahmet Ferit Dalgacı 2
1. Department Of Gynecology And Obstetrics, Yildirim Beyazit University School Of University, Ankara, Turkey
2. Department Of Gynecology And Obstetrics, Atatürk Training And Research Hospital, Ankara, Turkey
No information available.
No information available
Received Date: 15.02.2016
Accepted Date: 25.07.2016
PDF
Cite
Share
Request

ABSTRACT

Conclusion:

Low PAPP-A levels (≤0.5 MoM) in the first trimester are associated with the risk of intrapartum fetal distress development and the likelihood of C/S for fetal distress. Nonetheless, this risk is not affected by labor induction.

Results:

The mean gestational age at birth and the birth weights were significantly lower in Group 1 than in Group 2 (p=0.002 and p=0.007, respectively). Although the rate of C/S was similar between the groups (p=0.823), the rate of C/S due to fetal distress was significantly higher in Group 1 than in Group 2 (68.4% vs. 42%, respectively; p=0.050) and the mean umbilical artery blood pH value for C/S deliveries indicated by fetal distress was lower (p=0.048) in Group 1 than in Group 2. When the mode of delivery was analyzed according to the application of labor induction, both the C/S delivery rates (31.6% in Group 1 and 31.7% in Group 2; p=0.992) and C/S delivery rates due to fetal distress (66.7% in Group 1 and 46.2% in Group 2; p=0.405) were similar in both groups.

Material and Methods:

This retrospective study included 283 uncomplicated pregnancies that resulted in full-term live births via spontaneous labor or with the induction by oxytocin. Cases were divided into two groups based on whether their first-trimester PAPP-A multiple of the median (MoM) levels were ≤0.5 (Group 1, n=75) or >0.5 (Group 2, n=208). As primary end points, the rate of cesarean section (C/S), the rate of C/S due to fetal distress, and the umbilical artery blood pH values in cases of C/S for fetal distress were compared between the two groups. Statistical analyses were performed using the Chi-square test and independent samples t-test. P≤0.05 were considered statistically significant.

Objective:

To investigate the relationship between the development of intrapartum fetal distress and serum pregnancy-associated plasma protein-A (PAPP-A) levels measured during first-trimester aneuploidy screening tests.