E-ISSN: 1309-0380
    The influence of body mass index on FSH dose and pregnancy rate in women undergoing ICSI-embryo transfer
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    Original Investigation
    VOLUME: 10 ISSUE: 1
    P: 1-5
    March 2009

    The influence of body mass index on FSH dose and pregnancy rate in women undergoing ICSI-embryo transfer

    J Turk Ger Gynecol Assoc 2009;10(1):1-5
    Mahmut Tuncay Özgün 1
    Semih Uludag 2
    Gökalp Öner 3
    Cem Batukan 1
    Ercan M. Aygen 1
    Yilmaz Sahin 1
    1. Erciyes University, Faculty Of Medicine, Department Of Obstetrics And Gynecology, Kayseri, Turkey
    2. Department Of Gynecology And Obstetrics, Faculty Of Medicine, Erciyes University, Kayseri, Turkey
    3. Department Of Obstetrics And Gynecology, Faculty Of Medicine, Erciyes University, Kayseri
    No information available.
    No information available
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    ABSTRACT

    OBJECTIVE:

    The aim of this study was to evaluate the influence of body mass index (BMI) on follicle stimulating hormone (FSH) dose and pregnancy rate in women undergoing ICSI- embryo transfer (ET).

    MATERIAL-METHOD:

    This prospective study included 604 women undergoing ICSI-ET between January 2006 and December 2007. Patients were classified into five groups according to their BMI: Group A (BMI <18.5 kg/m2), Group B (BMI 18.5 to 24.9 kg/m2),Group C (BMI between 25 and 29.9 kg/m2), Group D (BMI 30 to 35.9 kg/m2), Group E (BMI: ≥36 kg/m2).

    RESULTS:

    Total FSH doses for groups were 2087,5 I U(1200-4800), 2200 IU (750-7575), 2362,5 IU (900-7650), 3000 IU (1050-6975) and 3525 IU(1600-7800) respectively. The total FSH dose was significantly higher in Group E compared with those women in Groups A, B, C (p=0.001). Cancelled cycle rates were similar in all groups. The pregnancy rates per cycle were 30%, 40.9%, 32.8%, 14.4% and 18.2% respectively. The pregnancy rate per cycle was significantly higher in Group B than those women in Groups D and E, and it was also higher in Group C compared with those patients in Group D (p=0.038). The total FSH doses were significantly lower in Groups B and C than those in Groups D and E in patients with male infertility and in women with PCOS (p<0,001). The total FSH doses were similar in all five groups in patients with tubal factor infertility and in women with unexplained infertility.

    CONCLUSIONS:

    Obese women (BMI >30 kg/m2) required higher dose of gonadotropin for stimulation and they face a lower likelihood of pregnancy after ICSI.

    Keywords: Body mass index, ICSI, Ovarian response, Pregnancy rate

    References

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