ABSTRACT

To investigate the effect of fresh frozen plasma (FFP) infusion in the postpartum period on urine output, serum blood urine nitrogen (BUN) and creatinine levels i women with severe preeclampsia.

Clinical records of patients who evaluated as severe pre-eclampsia were reviewed between the 2001-2004. From the 134 cases, records of total 52 patients with oliguria were evaluated. Following the delivery, patients whose urine output was less than 0, 5 ml/kg per hour following the 3 consecutive hours were accepted as oliguric. Subjects those of which received FFP were classified as group I (n=29). Control group (n=23) consisted of subjects who infused crystalloid solution only. BUN, creatinine levels and urine output in a 24 hour period were recorded in the two groups. Changes in blood levels of BUN and creatinine and urine output were compared between the two groups after 24th hours.

In group I, there was no difference in BUN levels between basal and following FFP infusion (p=0.305). However, serum creatinine levels decreased following FFP infusion (p=0.017). In group II, there was no statistically significant change for BUN and creatinine levels following the 24 hour period of crystalloid infusion (p=0.09 and p=0.46, respectively;). Also at the end of the 24 hour period, BUN and creatinine levels were not significantly different between the two groups (p=0.24 and p=0.29, respectively). Mean urine output was 1498±568 ml/24 h in group I and 1368±447 ml/24 h in group II (p=0.67).

Fresh frozen plasma as a plasma volume expander to enhance intravascular volume and urine output in the postpartum period do not provide additional benefit for improvement of oliguria in women with severe preeclampsia.

Keywords: Fresh frozen plasma, severe pre-eclampsia, oliguria, creatinine