E-ISSN: 1309-0380
The Effects of Induction of Labor with Oxytocin and Misoprostol on Neonatal Bilirubin Levels
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Clinical Study
VOLUME: 8 ISSUE: 1
P: 54-57
March 2007

The Effects of Induction of Labor with Oxytocin and Misoprostol on Neonatal Bilirubin Levels

J Turk Ger Gynecol Assoc 2007;8(1):54-57
Esra Bulgan Kiliçdag 1
Hasan Kiliçdag 2
Ebru Tarim 3
Tayfun Bagis 4
Filiz Tiker 2
Filiz Yanik 1
1. Department Of Gynecology And Obstetrics, Faculty Of Medicine, Baskent University, Adana, Turkey
2. Department Of Pediatrics, Division Of Neonatology, Faculty Of Medicine, Baskent University, Adana, Turkey
3. Baskent Üniversitesi Tip Faku¨Ltesi Kadin Hastaliklari Ve Dogum A.B.D
4. Baskent Üniversitesi Tip Faku¨Ltesi, Kadin Hastaliklari Ve Dogum Anabilim Dali
No information available.
No information available
Received Date: 02.05.2006
Accepted Date: 20.10.2006
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ABSTRACT

CONCLUSION

We found no difference between labor induction with misoprostol or oxytocin in regard of neonatal hiperbilirubinemia. This finding might encourage the use of misoprostol, with it’s advantages of low cost, stability in relation to temperature, easy handling and storage, and easy administration.

RESULTS

Parity, maternal body mass index, gestational age, birth weight, sex distribution, and frequency of using epidural analgesia for labor were similar in the three groups. Cord blood sodium and hematocrit levels were not statistically different between the groups. The mean of bilirubin levels on day 2 and 4 in the control, oxitocin and misoprostol groups were 8.93 ± 3.90 - 10.40 ± 5.52 mg/dL, 9.93 ± 3.71- 12.32 ± 4.32 mg/dL, and 8.32 ± 3.48 - 9.91 ± 4.57mg/dL, respectively. Postpartum 2nd and 4th day bilirubin levels were not statistically different between the groups (p<0.05).

MATERIALS-METHODS

We included 89 patients who have delivered at the Baskent University Obstetrics and Gynecology Department. There were 34 patients in the spontaneous vaginal delivery group (control group), and 23 and 32 patients in the oxytocin and misoprostol group, respectively. Cord blood sodium and hematocrit levels, and postpartum day 2 and 4 bilirubin levels were measured.

OBJECTIVE

Hyperbilirubinemia, is the most common problem in term newborns. Studies on neonatal hyperbilirubinemia and the use of oxytocin for the induction of labor have conflicting results, but it has been widely accepted that oxytocin infusion during labor, increased the risk of neonatal hyperbilirubinemia. When searched at Medline for misoprostol and neonatal hyperbilirubinemia, which is nowadays more frequently as a labor induction agent, we were not able to find any study about this case. We aimed to investigate and compare the effect of oxytocin and misoprostol on neonatal bilirubin levels with spontaneous vaginal delivery.

Keywords:
Misoprostol, oxytocin, neonatal hyperbilirubinemia