ABSTRACT

We aimed to compare the serum mannose-binding lectin (MBL) levels in severe preeclampsia with those in uncomplicated pregnancies and healthy women and to investigate the correlation with serum biochemical markers.

This study included 27 patients with severe preeclampsia (Group 1); 27, with uncomplicated pregnancies (Group 2); and 25 healthy reproductive-age women (Group 3). We performed a complete blood count and measured the prothrombin time; activated partial thromboplastin time; international normalized ratio; and the serum levels of urea, creatinine, uric acid, aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, and MBL.

The mean serum MBL level was significantly higher (p < 0.05) in Group 1 than in Groups 2 and 3, while the MBL levels did not differ significantly between Groups 2 and 3 (p > 0.05). High MBL level was not correlated with age, blood pressure, complete blood count, haemostatic parameters, and liver and renal functions.

Serum MBL level increases significantly in severe preeclampsia, but is not correlated with the degree of the severity.

Keywords: Mannose-binding lectin, Preeclampsia