Evaluation of Ki-67 Immunostaining in the Differential Diagnosis of Low Grade Squamous Intraepithelial Lesion and Normal Cervix

J Turk Ger Gynecol Assoc 2007;8(3):285-289

1. Department Of Pathology, Faculty Of Medicine, Cumhuriyet University, Sivas, Turkey

2. Department Of Obstetrics And Gynecology, Faculty Of Medicine, Cumhuriyet University, Sivas, Turkey

3. Cumhuriyet Üniversitesi Tip Fakültesi, Patoloji Ana Bilim Dali, Sivas

4. Department Of Anesthesiology And Reanimation, Faculty Of Medicine, Cumhuriyet University, Sivas, Turkey

No information available.

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Received Date: 27.02.2007

Accepted Date: 29.05.2007

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ABSTRACT

MATERIAL-METHOD:

Thirty-four cervical specimens, in which 17cases were previously diagnosed as normal cervix and 17 cases were low-grade SILs, included in the study. Ki-67 immunohistochemical staining was performed using avidin biotin complex.

RESULTS:

After reevaluating the cases by means of histo-pathological and Ki-67 immunostaining features, 21 of 34 cases were diagnosed as normal cervix and 13 were diagnosed as low-grade SILs. Ki-67 index was higher in low-grade SILs (p<0.05). Although Ki-67 positive cell clusters was not observed in normal cervix, 77% of 13 low-grade SILs had positive cell clusters (p<0.05).

CONCLUSIONS:

Ki-67 immunostaining may be considered as an easy and reproducible technique in differential diagnosis of normal cervix and low-grade SIL.

Keywords:

Cervix, Ki-67, immunohistochemistry, low-grade squamous intraepithelial lesion