E-ISSN: 1309-0380
    Effect of body mass index and age on in vitro fertilization in polycystic ovary syndrome
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    Original Investigation
    VOLUME: 17 ISSUE: 2
    P: 83-90
    June 2016

    Effect of body mass index and age on in vitro fertilization in polycystic ovary syndrome

    J Turk Ger Gynecol Assoc 2016;17(2):83-90
    DOI: 10.5152/jtgga.2016.15235
    Müberra Namlı Kalem 1
    Ziya Kalem 2
    Tamer Sarı 2
    Can Ateş 3
    Timur Gürgan 2
    1. Department Of Obstetrics And Gynecology, Turgut Özal University School Of Medicine, Ankara, Turkey
    2. Gürgan Clinic Ivf Center, Ankara, Turkey
    3. Department Of Biostatistics, Ankara University School Of Medicine, Ankara, Turkey
    No information available.
    No information available
    Received Date: 31.12.2015
    Accepted Date: 08.03.2016
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    ABSTRACT

    Objective:

    The aim of this study was to investigate age-related variations in the effect of body mass index (BMI) on in vitro fertilization (IVF) outcomes.

    Material and Methods:

    This was a cohort study conducted by retrospectively investigating the IVF cycles of 653 polycystic ovary syndrome (PCOS) patients under the age of 40 years who were diagnosed based on the Rotterdam criteria in a private IVF clinic between 2005 and 2015. The study included data from 653 IVF cycles of PCOS patients. The patients were classified into three groups based on their BMI, i.e., normal weight (n=299), overweight (n=208), and obese (n=146). The patients were also grouped by age: 562 patients were under the age of 35 years and 91 patients were above the age of 35 years. Then, BMI- and age-related variations in the IVF cycle parameters and clinical pregnancy rates of patients with PCOS were investigated. The Mantel–Haenszel Chi-square statistical assessment method was used to determine whether the effect of BMI on IVF outcomes varies with age.

    Results:

    Variations in cycle variables with BMI and age showed that IVF cycles were negatively affected by increases in obesity and age. Clinical pregnancy rates were found to be lower in the obese group than in the other groups, particularly in the age group above 35 years; however, this difference could not be proven statistically.

    Conclusion:

    The present study evaluated obesity and clinical pregnancy rates in IVF cycles in PCOS patients according to age groups, and particularly in the obese group, the clinical pregnancy rates were observed to be lower in the age group ≥35 years than in the other BMI groups; however, this difference was found to be statistically insignificant.

    Keywords: PCOS, body mass index, age, IVF outcome

    References

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