INTRODUCTION:

Gonadotropin-releasing hormone agonists are being increasingly used in infertility and gynaecological practice for treatment of fibroids, endometriosis and in vitro fertilization cycles.

CASE:

A 24-year-old nulliparous lady with a fibroid uterus had an inadvertent exposure to two doses of leuprolide acetate and conceived spontaneously while awaiting hysteroscopic myomectomy. The fetus suffered anomalies of urogenital system and sudden intrauterine fetal demise at 31 weeks gestation.

CONCLUSION:

Till date, no consensus has been gathered on the management of gonadotropin-releasing hormone agonist exposed pregnancies, risk of teratogenecity and perinatal outcome.

Keywords: Gonadototropin-releasing hormone agonist, congenital anomaly, fetal outcome