Original Investigation

Melatonin Treatment Results in Regression of Endometriotic Lesions in An Ooferectomized Rat Endometriosis Model


  • Nilüfer Çetinkaya
  • Rukset Attar
  • Gazi Yıldırım
  • Cem Fıçıcıoğlu
  • Ferda Özkan
  • Bayram Yılmaz
  • Narter Yeşildağlar

Received Date: 15.04.2013 Accepted Date: 24.04.2013 J Turk Ger Gynecol Assoc 2013;14(2):81-86 PMID: 24592080


We aimed to determine the effects of melatonin treatment on endometrial implants in an oopherectomized rat endometriosis model.

Material and Methods:

This study is a prospective, randomised, controlled experimental study. It was carried out at the Experimental Research Center of Yeditepe University (YUDETAM). Twenty-two, female, non-pregnant, nulligravid Spraque-Dawley albino rats were included in our study. Endometriosis was surgically induced in oopherectomized rats. Rats were randomised into two groups: control group and melatonin group. In the melatonin group, rats were treated with melatonin (20 mg/kg/day) for two weeks. After the operations were performed to assess the regression of the endometriotic lesions, melatonin treatment was stopped. At the end of the sixth week necropsies were performed to assess the rate of recurrence. The volume and histopathological scores of endometriotic foci were examined.


Volumes of the endometriotic lesions significantly decreased in the melatonin group. Also, when the melatonin group was analysed within itself, endometriotic lesion volumes decreased and histopathological scores increased significantly.


Melatonin causes regression of the endometriotic lesions in rats and improvement in their histopathological scores.

Keywords: Endometriosis, oopherectomized rats, volume, histopathological score, melatonin