We report a case of pericardial effusion induced by methotrexate in a patient with low risk gestational trophoblastic neoplasia, who had been taking the first course of sequential methotrexate-folinic acid treatment. After aspiration of pericardial effusion another methotrexate- folinic acid course was given and the pericardial effusion did not relapse.

Keywords: Methotrexate, toxicity, pericardial effusion, gestational trophoblastic neoplasia, treatment