Review

A systematic review of the reproductive and oncologic outcomes of fertility-sparing surgery for early-stage cervical cancer

10.4274/jtgga.galenos.2022.2022-9-7

  • Farr Nezhat
  • Hadi Erfani
  • Camran Nezhat

Received Date: 09.09.2022 Accepted Date: 01.12.2022 J Turk Ger Gynecol Assoc 2022;23(4):287-313 PMID: 36482657

In this review, we aim to evaluate the current literature on reproductive and oncologic outcomes after fertility-sparing surgery for early-stage cervical cancer (stage IA1-IB1). This is a systematic review of the existing literature using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) checklist to report on fertility-sparing surgery and its outcomes in early-stage cervical cancer. Outcomes of interest were subsequent clinical pregnancy rate, reproductive outcomes, and cancer recurrence outcomes. Included in this systematic review were 68 studies encompassing 3,592 patients who underwent fertility-sparing surgery. Of these, reproductive outcomes were reported in 1096 pregnancies. The mean clinical pregnancy rate was 53.2%. Those who underwent vaginal radical trachelectomy had the highest clinical pregnancy rate (67.5%). The mean live birth rate was 67.8% in our study. Twenty-one percent of pregnancies after fertility-sparing surgery required assisted reproductive technology. The mean cancer recurrence rate was 3.2%, and the cancer death rate was 0.6% after a median follow-up period of 40.1 months with no statistically significant difference across surgical approaches. Offering fertility-sparing surgery in early-stage cervical cancer is reasonable. Highest clinical pregnancy rate is associated with vaginal radical trachelectomy. Moreover oncologic outcomes of minimally invasive approaches were comparable with abdominal approaches. We encourage detailed preoperative counseling and multidisciplinary approach to achieve best outcomes.

Keywords: Cervical cancer, fertility-sparing surgery, pregnancy outcomes

Introduction

Cervical cancer is the fourth most common malignancy in women worldwide (1). The incidence of cervical cancer is reported to be highest between 35 and 49 years of age and decreases after that. In women between 20 to 45 years of age, this incidence has been reported as as 47.3 per 100,000 (2). Based on the International Federation of Gynecology and Obstetrics 2019 classification system, imaging data and pathology information are used to supplement clinical findings to stage cervical cancer. Details of this staging system is included in Table 1 (3,4). Global Papanicolaou screening and human papillomavirus vaccination have resulted a significant decline in the rate of cervical cancer. Currently the National Cancer Institute reports 90% 5-year survival rate in patients with localized cervical cancer (2). Traditionally total hysterectomy, radical hysterectomy with or without lymphadenectomy, or chemoradiation have been considered the only treatment options for cervical cancer. Given the fact that approximately 40% of patients diagnosed with cervical cancer are in the reproductive age, attention to alternative treatment methods for surgical and/or functional preservation of the reproductive system and lead to uterine, tubal, or ovarian factor infertility is of importance (5). Fertility-sparing surgery for early-stage cervical cancer (stage IA1-IB1) is now a viable option that can be offered per the National Comprehensive Cancer Network guidelines. Current fertility sparing options are cervical conization, simple and radical trachelectomy. Trachelectomy can be done abdominally, vaginally, and laparoscopic with or without robot assistance.

The invention and development of video-assisted laparoscopy by Dr. Camran Nezhat has impacted and improved the minimally invasive options as the standard of care in many surgical disciplines including gynecologic oncology (6,7,8,9,10). Reports of the first video-assisted laparoscopic radical hysterectomy, paraaortic and pelvic lymphadenectomy which was performed the Nezhats in 1989 have been previously published (11,12). The early work of surgeons Dargent, Salvat, Querleu, Nezhat, and Childers later on proved the feasibility and safety of retroperitoneal lymphadenectomy (13,14,15,16). Roboticassisted radical trachelectomy and pelvic lymphadenectomy have also been reported for the first time by Chuang and Nezhat in 2008, after which other’s experiences have been published (17,18,19).

It is recommended that fertility-sparing surgery be offered to patients after extensive and detailed disclosure of risks, benefits and alternatives. Multidisciplinary meetings by gynecologic oncologists, infertility specialists and other appropriate services are strongly encouraged. Existing evidence offers fertility-sparing surgery in the setting of early-stage cervical cancer (IA1-IB1). In a prospective cohort study, 88 patients underwent laparoscopic radical trachelectomy for early-stage cervical cancer. Based on this study a tumor size of >2 cm was found to be associated with increased risk of cancer recurrence in the setting of fertility sparing surgery (as high as 20%) (20,21).

In patients with more advanced stage disease, those with more aggressive tumor histology like adenoma malignum, gastric adenocarcinoma, clear cell adenocarcinoma, embryonal rhabdomyosarcoma or small cell cancer, and those with no future fertility planning, fertility sparing options are contraindicated and definitive management should be offered. Even in those who undergo fertility sparing treatments radical hysterectomy should be offered when the fertility is no longer desired or when there is persistent HPV abnormality (3).

Based on retrospective and non-randomized research minimally invasive approach to radical hysterectomy for early-stage cancer is being considered safe and is associated with less short-term and long-term morbidity including shorter hospital stay, decreased blood loss (22,23,24,25,26,27,28,29,30). In a research that was done by Wang et al. (31) it was concluded that both 5-year recurrence free survival and overall survival rates are similar in laparoscopic versus abdominal radical hysterectomies. Another study in 2008 also concluded that the 3-year recurrence free survival and overall survival rates are similar in laparoscopic versus robotic radical hysterectomies for early-stage cervical cancer (32). After the the Laparoscopic Approach to Cervical Cancer (LACC) trial by Ramirez et al. (33), definitive management of early-stage cervical cancer in being considered via laparotomy route in many institutions. This study concluded that radical hysterectomy via minimally invasive routes are associated with lower rates of disease-free and overall survival rates as compared to open surgery. This is the only randomized trial to date that reports the comparison of outcomes of open approach versus minimally invasive options. This study was statistically powered as a noninferiority study with primary endpoint of disease-free survival at 4.5 years. Subjects were randomized to radical hysterectomy by either an abdominal or minimally invasive (laparoscopic or robotic-assisted) approach. The data and safety monitoring committee ended the study in June 2017 due to a safety issue with one of the blinded surgical treatment arms in one of the interim analyses. The authors reported the outcomes on 312 subjects in the abdominal hysterectomy arm versus 319 subjects under the minimally invasive arm (83% laparoscopy, 16% robotic surgery). The disease-free survival rate was 96.5% in the abdominal hysterectomy arm as compared to 86% in the minimally invasive surgery arm based on the intention to treat analysis; this corresponds to 13% difference decrease in hazard of death in open surgery arm. Moreover, the number of total disease recurrences in the minimally invasive arm was about four times higher than the number of recurrences after open surgery (27 vs. 7). In this research a significantly lower overall survival was reported in the minimally invasive arm (3 of 312 vs. 19 of 319; HR: 6.00; 95% confidence interval: 1.48-20.3; p=0.004). Based on this finding, the open approach was presented as the preferred route of radical hysterectomy for early-stage cervical cancer. There are some significant limitations associated with the LACC trial. 1) The minimally invasive arm was significantly skewed towards laparoscopic approach over robotic approach, which might not be an appropriate reflection of current practices. 2) In this study the majority of subjects were stage IB1. 3) There was a significant lack of detailed histopathologic data in the final study report. 4) The specific preoperative imaging strategy, and adequate follow up was lacking. 5) Additionally, as a multinational multicenter study in 33 surgical cneters around the world different surgical skills are not unexpected. All the recurrences had happened in 14 out of 33 recruiting centers however no additional informal is provided in the publication regarding details of surgical methodology and perioperative management in any of the other recurrence free institutes. Therefore, the surgical practices and techniques may have contributed significantly as confounding variables. The authors of this paper believe that the conclusion of of the LACC trial should be inetpreted with caution (34). We are in agreement with Donnez (35) who hypothesized that survival differences between minimally invasive and open surgeries will diminish with more surgical experience in minimally invasive approaches. In 2020, an international European cohort observational study compared minimally invasive surgery versus open abdominal radical hysterectomy in a patient with stage IB1 cervical cancer (36). They concluded that minimally invasive surgery in cervical cancer is associated with an increased risk of relapse and death as compared to open surgery. However, it is worth mentioning that in that study, by avoiding uterine manipulators and by using maneuvers to avoid tumor spread at the time of colpotomy in minimally invasive surgeries, outcomes were similar to open surgery.

At a time when open approach is recommended for management of early cervical cancer there is lack of evidence on the route of radical trachelectomy specifically. It is also unclear if the surgical approach (open versus minimally invasive) will affect the final cancer related outcomes.

In this study, we aim to report the result of systematic evaluation of current literature on fertility sparing interventions for early-stage cervical cancer and their associated cancer related, reproductive and obstetric outcomes.


Material and Methods

This paper is a systematic review of the current literature on fertility-sparing surgery for early-stage cervical cancer and the associated reproductive, obstetrics and oncologic outcomes. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist was utilized. Medline database used to review the literature. The screening query was “uterine cervical neoplasms” AND “gynecoogic surgical procedures” AND “infertility.” We then performed a Medline search for the query “fertility-sparing surgery” and “cervical cancer.” Two independent authors reviewed the results. This study was exempt from institutional review board approval since there is no human subject research involved.

Included fertility sparing procedures were conization, vaginal radical trachelectomy, open radical trachelectomy, simple trachelectomy with and without lymphadenectomy, or minimally invasive radical trachelectomy (laparoscopic with or without robotic assistance). Literature were included if they specified pregnancy and/or reproductive outcomes per surgical approach. Only papers written in English language between May 1980 and August 2021 were included. Figure 1 depicts the details of the identification process. We excluded the studies that addressed subjects with greater than stage IB1, or those with tumor size >2 cm or those who underwent experimental procedures. Unusual pathologies other than squamous cell carcinoma, adenocarcinoma, or adenosquamous carcinoma were excluded too. Table 1 shows cervical cancer stages and associated fertility-sparing surgical treatments. D Any review article without any new patient data or any case reports or case series that addressed fewer than 2 subjects were also excluded. PubMed was last screened on 5 August 2021.

Our outcome variables were: live birth rate, clinical pregnancy rate, as well as rates for preterm delivery, cancer related death and cancer recurrence. We divided the number of subjects with minimum of one pregnancy to the number of those who were trying to conceive and defined the clinical pregnancy rate. When the number of patients who were conceiving was not reported; the absolute number of patients with at least one pregnancy was included instead. Preterm delivery was defined as delivery between 24- and 36-weeks’ gestation. Per different surgical protocols some of the subjects had intact superior branches of the uterine artery versus in some the arteries were ligated at the origin; this rate was reported as percentage. Recommendation on delay in conception postoperatively was also addressed and reported.


Statistical Analysis

Analysis of variance (one tailed) with post-hoc Tukey tests were used for comparison. The p-value was calculated by the software as a function of F statistic and degrees of freedom for study numerator and denominators. Statistical analysis was performed using SPSS version 23.0. P<0.05 was considered statistically significant.


Results

A total of 68 studies were included in this study. Tables 2, 3, 4, 5, 6 show the data on 3592 patients based on surgical treatment (3738,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94,95,96,97,98,99,110,111,112).

Of the total of 3,592 subjects who underwent fertility-sparing surgery, 1,391 (39%) attempted to conceive, resulting in 1,097 pregnancies. The subjects were followed up for a median of 41 months after their fertility sparing procedure. In 20 studies trying for conception was delayed between 3 to 48 months to monitor for cancer related symptoms prior to conception. The rate for cervical stenosis was 4.7% (169 patients).  Analysis of mode of conceptions revealed the rates of 79%, and 29% for spontaneous conception versus assisted reproductive technology (ART) [including in-vitro fertilization, intrauterine insemination (IUI) with or without ovulation induction or cervical dilation with IUI], respectively.

Number of patients who were trying to conceive was reported in 49 studies; the mean clinical pregnancy rate after cancer treatment was 53.2% in this population. Further statistical evaluation of association of surgical approach and clinical pregnancy rate revealed higher rate in vaginal as compared with abdominal radical trachelectomy (67.5±20.0% versus 39.8±15.1%; p<0.01). No statistically significant association was found for other surgical routes.

The rate of live birth was reported in 62 studies revealing the mean rate of 67.8%. Further statistical evaluation of association of surgical approach and live birth rate revealed a higher live birth rate in subjects who underwent simple trachelectomy or conization (86.4±16.8%) as compared to vaginal radical trachelectomy (63.4±23.3%; p=0.04) and laparoscopic radical trachelectomy with or without robotic assistance (57.3±17.1%; p=0.03). No difference in this rate was found among other surgical approaches.

The rate of preterm delivery was reported in 51 studies revealing the mean rate of 29% after all fertility sparing surgical approaches. There was no association between this rate and the various surgical approaches (F=0.22; p=0.8). No association between various surgical approaches and the second trimester loss rate (8.2%) was found either (F=0.385; p=0.764).

The superior branches of the uterine artery remained intact in 100% of patient who underwent simple trachelectomy or conization, 88.9% of those who underwent vaginal radical trachelectomy, 44.6% of those who underwent abdominal radical trachelectomy, and 58.8% of those who underwent laparoscopic radical trachelectomy. The postoperative infections reported as follows: pelvic lymphocyst in 9 patients, pelvic inflammatory disease in 6 patients, pelvic abscess in 6 patients, pelvic peritonitis in 2 patients, and “pelvic infection” in one patient.

The cancer recurrence rate and cancer death rate after fertility-sparing procedure was reported in 65 studies. The overall mean cancer recurrence rate was 3.2%; no statistically significant association was found between this rate and the surgical approach (F=0.536; p=0.659). The overall mean cancer death rate was 0.7% with no significant association with surgical approach either (F=1.759, p=0.163).


Discussion

Our study shows that among all fertility-sparing treatments, vaginal radical trachelectomy has the highest clinical pregnancy rate (67%). Vaginal radical trachelectomy is a minimally invasive technique that can be associated with decreased rate of intraabdominal and pelvic adhesions. This approach is also associated with spared superior branches of uterine artery by the end of procedure. On the other hand, there is a higher potential to develop tuboovarian adhesion (as a known tubal factor for infertility) in the setting of abdominal procedure. Moreover, uterine arteries are ligated most of the times in the setting of abdominal radical trachelectomy; which may theoretically be associated with fertility rate (100). In a study by Tang et al. (101) patients with open procedure underwent computed tomography (CT) angiograms. Assessment of those with spared versus ligated uterine artery and the association with infertility was done. Interestingly, their study revealed that 87.5% of anatomically preserved uterine arteries occluded after surgery and overall 65.4% of subjects developed appropriate collateral circulation to perfuse their uteri (101). In another study by Muraji et al. (102), 18 subjects who underwent open radical trachelectomy with only inferior uterine artery branch ligation were studied and AMH level compared with control group; this study found no statistically significant difference in AMH as an index of ovarian reserve between cases and controls (102). This implies that ovarian reserve is likely unaffected by the ligation of inferior branches of uterine artery.


Obstetric outcomes

Per our systematic review revealed that the live birth rate was highest to lowest in simple trachelectomy/conization, followed by abdominal and then vaginal and then laparoscopic radical trachelectomy. Although those who underwent simple trachelectomy/cervical conization had the highest live birth rate as compared to all the other approaches, this can be attributed to selection bias with more advanced cancers are more likely to be treated via other routes. None of the reviewed studies mentioned cervical insufficiency as a potential complication of the fertility sparing procedures. We used second trimester pregnancy loss as a proxy for this variable and found to statistically significant difference across various surgical approaches.

We reported a 31% risk of preterm delivery after fertility sparing procedures. This rate seems to be significantly more than the 10.6% baseline risk in the general population (103). As a result of surgeon preference, some patients undergo a cervical cerclage placement at the time of trachelectomy routinely. To the best of our knowledge, there are no high-level evidence is available to date to support this intervention and its efficacy in preventing preterm delivery in the setting of fertility sparing surgery (17,40,54,73,104,105). We believe that all patients after fertility sparing procedures should be referred to maternal fetal medicine specialists for antepartum management.

Sufficient data and protocols to decrease the rate of preterm delivery in this population is lacking. One study found that magnetic resonance imaging (MRI) measurement of residual cervical length after radical trachelectomy might be a reliable predictor of preterm delivery or PPROM with significantly increased risk for cervical lengths <10 mm (105). Another study reported that a cervical length of less than 13 mm after abdominal radical trachelectomy was associated with increased risk of preterm delivery; they concluded that a routine second-trimester ultrasound screening can be used as a reliable screening measure (105).


Cervical stenosis

Our study revealed that about 5% of patients were diagnosed with cervical stenosis during their postoperative course. Based on the available data from the existing literature, it is unclear which exact types of fertility treatments were required in the setting of post procedure cervical stenosis. Only 40% of patients were trying to conceive during the study period after their fertility sparing surgery; although the reasons are unclear but potential associated factors can be planned delayed childbearing, postoperative dyspareunia or decreased libido. This topic deserves a further studies in future.


Cancer related outcomes

Based on our review, there was no association between in the different surgical approaches and the cancer recurrence or cancer death rate. Moreover, the authors believe that similar benefits to laparoscopic radical hysterectomy can be achieve by performing laparoscopic radical trachelectomy with or without robotic assistance. These benefits include and are not limited to lower short- and long term moribidity, decreased blood loss and shorter hospital stay.

Since this is a relatively new procedure, we recommend that patients should be referred to centers of excellence in gynecologic oncology with extensive experience in the evaluation and surgical management of early-stage cervical cancer. In brief, our recommendation is to perform a thorough histopathologic and preoperative evaluation. Performing a pelvic MRI, contrast axial CT, and positron emission tomography for proper assessment of the parametrium and possible lymphadenopathy is encouraged.

The LACC trial recently provided the notion that use of uterine manipulator might be associated with cancer recurrence and decreased survival rate. For that reason, our recommendation is to avoid uterine manipulators especially in the setting of a visible cervical lesion. At times and if no visible cervical lesion is present, after the cervix and parametrium are completely mobilized and resected the uterine manipulator to assist with making colpotomy can be used. We recommend removing the specimen immediately after transected from the vagina and maybe in a specimen retrieval bag. Appropriate radicality of the procedure should be assessed by confirming cancer free margins. Anastomosis of the vagina to uterine corpus and possible cerclage placement can be done either laparoscopically or vaginally per surgeon’s preference. In the setting that there is visible disease on cervix, laparoscopic approach can be used to mobilize the cervix and dissect the parametrium and then the procedure can be converted to vaginal route. Colpotomy can be done vaginally with adequate margins. We recommend to bring the vaginal mucosa over the cervix at this point and clamp with appropriate instruments to cover the diseased cervix. The cervix should be amputated with negative margins and then the reanastomosis procedure can be continued vaginally. We believe that the role of surgeon’s learning curve in the outcomes of these minimally invasive procedures is significant; this will make designing a randomized controlled trials comparing laparoscopic radical trachelectomy, with and without robotic assistance, and other surgical approaches hard.


Conclusion

Our study has several strengths. To the best of our knowledge, this is the largest and most comprehensive review of obstetrics, reproductive and fertility outcomes of fertility sparing methods in the setting of early-stage cervical cancer. To calculate the clinical pregnancy rate, we included only those who were trying to conceive as opposed to all the patients who undergone fertility sparing procedure.

Potential limitations of our study were limitations of data presented in the literature, with a lack of control over confounders that may affect oncologic or reproductive outcomes. This includes previous infertility or potential comorbid diagnosis. Also there were limited information regarding the details of the ART methods and protocols in primary literature.

Although no statistically significant difference was found in the preterm delivery rate across different fertility sparing approaches, the data for iatrogenic preterm deliveries was not available in the primary literature. Initially obstetricians tend to iatrogenically deliver their patient at 34 weeks, after fertility sparing procedures (62,104). Since the use of cerclage to prevent preterm delivery is not supported by high level evidence-based literature patients recently have been scheduled for delivery closer to term (108). For this reason there is an iatrogenic component in higher rate of preterm delivery in older and compared to more recent literature.

Attention to multiple factors is required to determine the optimal approach to fer-tility sparing procedure in early-stage cervical cancer. Patient’s preference, disease’s stage, surgeon’s experience and available surgical instrumentation are some of these important factors. In this review, we provided the most updated relevant data that can be used in preoperative counseling. Further research in high volume surgical centers are encouraged to address the outcomes of minimally invasive radical trachelectomy in more details. We encourage multidisciplinary patient counseling, with gynecologic oncologists, reproductive endocrinologists, and maternal fetal medicine specialists present to set reasonable expectations regarding treatment and outcomes.


Peer-review: Externally and internally peer-reviewed.

Conflict of Interest: No conflict of interest is declared by the authors.

Financial Disclosure: The authors declared that this study received no financial support.

  1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics for 36 cancers in 185 countries. CA Cancer J Clin 2018; 68: 394-424.
  2. U.S. Cancer Statistics Working Group. U.S. Cancer Statistics: Data Visualizations Tool. Based on November 2018 submis-sion data (1999-2016). Atlanta, GA: U.S. Department of Health and Human Services, Centers for Disease Control and Preven-tion and National Cancer Institute. Available at: https://www.cdc.gov/cancer/dataviz.
  3. Koh WJ, Abu-Rustum NR, Bean S, Bradley K, Campos SM, Cho KR, et al. Cervical cancer, version 3.2019, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw 2019; 17: 64-84.
  4. Bhatla N, Berkeley JS, Cuello FM, Denny LA, Grenman S, Karunaratne K, et al. Revised FIGO staging for carcinoma of the cervix uteri. Int J Gynaecol Obstet 2019; 145: 129-35.
  5. Seli E, Tangir J. Fertility preservation options for female patients with malignancies. Curr Opin Obstet Gynecol 2005; 17: 299-308.
  6. Jr WEK. The evolution of laparoscopy and the revolution in surgery in the decade of the 1990s. JSLS 2008; 12: 351-7.
  7. Nezhat C, Nezhat F, Nezhat C. Endometriosis: ancient disease, ancient treatments. Fertil Steril 2012; 98(Suppl): S1-62.
  8. Podratz K. Degrees of freedom: advances in gynecological and obstetrical surgery. remembering milestones and achieve-ments in surgery. Chicago: American College of Surgeons; 2012. Available at: http://nezhat.org/wpcontent/uploads/2019/08/Degrees-of-Freedom-Advances-in-Gynecologi cal-and-Obstetrical-Surgery.pdf
  9. Tokunaga R. Video surgery expands its scope. Stanford Med 1993/1994; 11:12-6.
  10. Page B. Nezhat & the rise of advanced operative video-laparoscopy. In: Nezhat C, editor. Nezhat’s history of endoscopy. Tuttlingen, Germany: Endo Press; 2011:159-87, Available at: https://laparoscopy.blogs.com/endoscopyhistory/chapter_22/index.html.
  11. Nezhat CR, Nezhat FR, Silfen SL. Videolaseroscopy: the CO2 laser for advanced operative laparoscopy. Obstet Gynecol Clin North Am 1991; 18: 585-604.
  12. Nezhat CR, Burrell MO, Nezhat FR, Benigno BB, Welander CE. Laparoscopic radical hysterectomy with paraaortic and pelvic node dissection. Am J Obstet Gynecol 1992; 166: 864-5.
  13. Dargent D, Salvat J. Envahissement Ganglionnaire Pelvien. Paris: MEDSI; 1989.
  14. Querleu D, Leblan E, Catelain B. Laparoscopic pelvic lymphadenectomy in the staging of early carcinoma of the cervix. Am J Obstet Gynecol 1991; 164: 579-81.
  15. Nezhat CR, Nezhat FR, Burrell MO, Ramirez CE, Welander C, Carrodeguas J, et al. Laparoscopic radical hysterecto-my and laparoscopic assisted radical vaginal hysterectomy with pelvic and paraaortic node dissection. J Gynecol Surg 1993; 9: 105-20.
  16. Childers JM, Hatch KD, Tran AN, Surwit EA. Laparoscopic para-aortic lymphadenectomy in gynecologic malignancies. Obstet Gynecol 1993; 82: 741-7.
  17. Persson J, Kannisto P, Bossmar T. Robot-assisted abdominal laparoscopic radical trachelectomy. Gynecol Oncol 2008; 111: 564-7.
  18. Geisler JP, Orr CJ, Manahan KJ. Robotically assisted total laparoscopic radical trachelectomy for fertility sparing in stage IB1 adenosarcoma of the cervix. J Laparoendosc Adv Surg Tech A 2008; 18: 727-9.
  19. Chuang LT, Lerner DL, Liu CS, Nezhat FR. Fertility-sparing robotic assisted radical trachelectomy and bilateral pelvic lym-phadenectomy in early-stage cervical cancer. J Minim Invasive Gynecol 2008; 15: 767-70.
  20. Park JY, Joo WD, Chang SJ, Kim DY, Kim JH, Kim YM, et al. Long-term outcomes after fertility-sparing laparoscopic radical trachelectomy in young women with early-stage cervical cancer: an Asian Gynecologic Cancer Group (AGCG) study. J Surg Oncol 2014; 110: 252-7.
  21. Rob L, Skapa P, Robova H. Fertility-sparing surgery in patients with cervical cancer. Lancet Oncol 2011; 12: 192-200.
  22. Zakashansky K, Chuang L, Gretz H, Nagarsheth NP, Rahaman J, Nezhat FR. A case-controlled study of total laparoscopic radical hysterectomy with pelvic lymphadenectomy versus radical abdominal hysterectomy in a fellowship training pro-gram. Int J Gynecol Cancer 2007; 17: 1075-82.
  23. Lee EJ, Kang H, Kim DH. A comparative study of laparoscopic radical hysterectomy with radical abdominal hysterectomy for early-stage cervical cancer: a long-term follow-up study. Eur J Obstet Gynecol Reprod Biol 2011; 156: 83-6.
  24. Nam JH, Park JY, Kim DY, Kim JH, Kim YM, Kim YT. Laparoscopic versus open radical hysterectomy in early-stage cervical cancer: long-term survival outcomes in a matched cohort study. Ann Oncol 2012; 23: 903-11.
  25. Frumovitz M, dos Reis R, Sun CC, Milam MR, Bevers MW, Brown J, et al. Comparison of total laparoscopic and abdominal radical hysterectomy for patients with early-stage cervical cancer. Obstet Gynecol 2007;110: 96-102.
  26. Malzoni M, Tinelli R, Cosentino F, Fusco A, Malzoni C. Total laparoscopic radical hysterectomy versus abdominal radical hysterectomy with lymphadenectomy in patients with early cervical cancer: our experience. Ann Surg Oncol 2009; 16: 1316-23.
  27. Soliman PT, Frumovitz M, Sun CC, Dos Reis R, Schmeler KM, Nick AM, et al. Radical hysterectomy: a comparison of surgical approaches after adoption of robot-ic surgery in gynecologic oncology. Gynecol Oncol 2011; 123: 333-6.
  28. Sert BM, Boggess JF, Ahmad S, Jackson AL, Stavitzski NM, Dahl AA, Holloway RW. Robot-assisted versus open radical hysterectomy: a multi-institutional experience for early-stage cervical cancer. Eur J Surg Oncol 2016; 42: 513-22.
  29. Shah CA, Beck T, Liao JB, Giannakopoulos NV, Veljovich D, Paley P. Surgical and oncologic outcomes after robotic radical hysterectomy as compared to open radical hysterectomy in the treatment of early cervical cancer. J Gynecol Oncol 2017; 28: e82.
  30. Shazly SA, Murad MH, Dowdy SC, Gostout BS, Famuyide AO. Robotic radical hysterectomy in early-stage cervical cancer: a systematic review and meta-analysis. Gynecol Oncol 2015; 138: 457-71.
  31. Wang W, Chu HJ, Shang CL, Gong X, Liu TY, Zhao YH, et al. Long-term oncological outcomes after laparoscopic versus ab-dominal radical hysterectomy in stage IA2 to IIA2 cervical cancer: a matched cohort study. Int J Gynecol Cancer 2016; 26: 1264-73.
  32. Gallotta V, Conte C, Federico A, Vizzielli G, Gueli Alletti S, Tortorella L, et al. Robotic versus laparoscopic radical hysterec-tomy in early cervical cancer: a case matched control study. Eur J Surg Oncol 2018; 44: 754-9.
  33. Ramirez PT, Frumovitz MD, Pareja R, Lopez A, Vieira M, Ribeiro R, et al.  Minimally invasive versus abdominal radical hysterectomy for cervical cancer. N Engl J Med 2018; 379: 1895-904.
  34. Nezhat FR, Ananth CV, Vintzileos AM. Two Achilles heels of surgical randomized controlled trials: differences in surgical skills and reporting of average performance. Am J Obstet Gynecol 2019; 221: 230-2.
  35. Donnez J. Unexpected results from randomized clinical trials. Or are they? Fertil Steril 2019; 11: 804-5.
  36. Chiva L, Zanagnolo V, Querleu D, Martin-Calvo N, Arévalo-Serrano J, et al. SUCCOR study: an international European co-hort observational study comparing minimally invasive surgery versus open abdominal radical hysterectomy in patients with stage IB1 cervical cancer. Int J Gynecol Cancer 2020; 30: 1269-77.
  37. Bogani G, Chiappa V, Vinti D, Somigliana E, Filippi F, Murru G, et al. Longterm results of fertility-sparing treatment for early-stage cervical cancer. Gynecol Oncol 2019; 154: 89-94.
  38. Okugawa K, Kobayashi H, Sonoda K, Kaneki E, Kawano Y, Hidaka N, et al. Oncologic and obstetric outcomes and compli-cations during pregnancy after fertility-sparing abdominal trachelectomy for cervical cancer: a retrospective review. Int J Clin Oncol 2017; 22: 340-6.
  39. Plante M, Renaud MC, Sebastianelli A, Gregoria J. Simple vaginal trachelectomy: a valuable fertility-preserving option in early-stage cervical cancer. Int J Gynecol Cancer 2017; 25: 1021-7.
  40. Andikyan V, Khoury-Collado F, Denesopolis J, Park KJ, Hussein YR, Brown CL, et al. Cervical conization and sentinel lymph node mapping in the treatment of stage I cervical cancer: is less enough? Int J Gynecol Cancer 2014; 24: 113-7.
  41. Fanfani F, Landoni F, Gagliardi ML, Fagotti A, Preti E, Moruzzi MC, et al. Sexual and reproductive outcomes in early-stage cervical cancer patients after excisional cone as a fertility-sparing surgery: an Italian experience. J Reprod Infertil 2014; 15: 29-34.
  42. Lindsay R, Burton K, Shanbhag S, Tolhurt J, Milan D, Siddiqui N. Fertility conserving management of early cervical cancer: our experience of LLETZ and pelvic lymph node dissection. Int J Gynecol Cancer 2014; 24: 118-23.
  43. Biliatis I, Kucukmetin A, Patel A, Ratnavelu N, Cross P, Chattopadhyay S, et al. Small volume stage IB1 cervical cancer: is radical surgery still neces.sary? Gynecol Oncol 2012; 126: 73-7.
  44. Palaia I, Musella A, Bellati F, Marchetti C, Di Donato V, Perniola G, et al. Simple extrafascial trachelectomy and pelvic bilateral lymphadenectomy in early-stage cervical cancer. Gynecol Oncol 2012; 126: 78-81.
  45. Raju SK, Papadopoulos AJ, Montalto SA, Coutts M, Culora G, Kodampur M, et al. Fertility-sparing surgery for early cervical cancer: approach to less radical surgery. Int J Gynecol Cancer 2012; 22: 311-7.
  46. Maneo A, Sideri M, Scambia G, Boveri S, dell’Anna T, Villa M, et al. Simple conization and lymphadenectomy for the con-servative treatment of stage IB1 cervical cancer: an Italian experience. Gynecol Oncol 2011; 123: 557-60.
  47. Rob L, Pluta M, Strnad P, Hrehorcak M, Chmel R, Skapa P, et al. A less radical treatment option to the fertility-sparing radical trachelectomy in patients with stage I cervical cancer. Gynecol Oncol 2008; 111: S116-20.
  48. McHale MT, Le TD, Burger RA, Gu M, Rutgers JL, Monk BJ. Fertility sparing treatment for in situ and early invasive adeno-carcinoma of the cervix. Obstet Gynecol 2001; 98: 726-31.
  49. Malmsten C, Hellberg P, Bergmark K, Dahm-Kahler P. Long-term fertility, oncological, and quality-of-life outcomes after trachelectomy in early-stage cervical cancer. Arch Gynecol Obstet 2019; 299: 1033-41.
  50. Wang A, Cui G, Jin C, Wang Y, Tian X. Multicenter research on tumor and pregnancy outcomes in patients with early-stage cervical cancer after fertility-sparing surgery. J Int Med Res 2019; 47: 2881-9.
  51. Wu CJ, Chang WC, Chen CH, Chen CA, Huang SC, Sheu BC. Radical trachelectomy for early stage cervical cancer: a case se-ries and literature review. Taiwan J Obstet Gynecol 2017; 56: 143-6.
  52. Zusterzeel PL, Pol FJ, van Ham M, Zweemer RP, Bekkers RL, Massuger LF, et al. Vaginal radical trachelectomy for early-stage cervical cancer: increased recurrence risk for adenocarcinoma. Int J Gynecol Cancer 2016; 26: 1293-9.
  53. Hauerberg L, Høgdall C, Loft A, Ottosen C, Bjoern SF, Mosgaard BJ, et al. Vaginal radical trachelectomy for early stage cervical cancer: results of the Danish National Single Center Strategy. Gynecol Oncol 2015; 138: 304-10.
  54. Kim M, Ishioka S, Endo T, Baba T, Akashi Y, Morishita M, et al. Importance of uterine cervical cerclage to maintain a suc-cessful pregnancy for patients who undergo vaginal radical trachelectomy. Int J Clin Oncol 2014;19: 906-11.
  55. Cao DY, Yang JX, Wu XH, Chen YL, Li L, Liu KJ, et al. Comparisons of vaginal and abdominal radical trachelectomy for early-stage cervical cancer: preliminary results of a multi-center research in China. Br J Cancer 2013; 109: 2778-82.
  56. Speiser D, Mangler M, Kohler C, Hasenbein K, Hertel H, Chiantera V, et al. Fertility outcome after radical vaginal trachelec-tomy: a prospective study of 212 patients. Int J Gynecol Cancer 2011; 21:1635-9.
  57. Speiser D, Kohler C, Schneider A, Mangler M. Radical vaginal trachelectomy: a fertility-preserving procedure in early cervi-cal cancer in young women. Dtsch Arztebl Int 2013; 110: 289-95.
  58. Kim CH, Abu-Rustum NR, Chi DS, Gardner GJ, Leitao MM Jr, Carter J, et al. Reproductive outcomes of patients undergoing radical trachelectomy for early-stage cervical cancer. Gynecol Oncol 2012; 125: 585-8.
  59. Persson J, Imboden S, Reynisson P, Andersson B, Borgfeldt C, Bossmar T. Reproducibility and accuracy of robot-assisted laparoscopic fertility sparing radical trachelectomy. Gynecol Oncol 2012; 127: 484-8.
  60. Uzan C, Gouy S, Desroque D, Pomel C, Duvillard P, Balleyguier C, et al. Analysis of a continuous series of 34 young patients with early-stage cervical cancer selected for a vaginal radical trachelectomy: should “staging” conization be systematically performed before this procedure? Int J Gynecol Cancer 2013; 23: 331-6.
  61. Plante M, Gregoire J, Renaud MD, Roy M. The vaginal radical trachelectomy: an update of a series of 125 cases and 106 pregnancies. Gynecol Oncol 2011; 121: 290.
  62. Knight LJ, Acheson N, Kay TA, Renninson JN, Shepherd JH, Taylor MJ. Obstetric management following fertility-sparing radical vaginal trachelectomy for cervical cancer. J Obstet Gynaecol 2010; 30:784-9.
  63. Chen Y, Xu H, Zhang Q, Li Y, Wang D, Liang Z. A fertility-preserving option in early cervical carcinoma: laparoscopy-assisted vaginal radical trachelectomy and pelvic lymphadenectomy. Eur J Obstet Gynecol Reprod Biol 2008; 136: 90-3.
  64. Pahisa J, Alonso I, Torne A. Vaginal approaches to fertility-sparing surgery in invasive cervical cancer. Gynecol Oncol 2008; 110(Suppl 2): S29-32.
  65. Sonoda Y, Chi DS, Carter J, Barakat RR, Abu-Rustum NR. Initial experience with Dargent’s operation: the radical vaginal trachelectomy. Gynecol Oncol 2008; 108: 214-9.
  66. Hertel H, Kohler C, Grund D, Hillemanns P, Possover M, Michels W, Schneider A. Radical vaginal trachelectomy (RVT) combined with laparoscopic pelvic lymphadenectomy: prospective multicenter study of 100 patients with early cervical can-cer. Gynecol Oncol 2006; 103: 506-11.
  67. Shepherd JH, Spencer C, Herod J, Ind TE. Radical vaginal trachelectomy as a fertility-sparing procedure in women with early-stage cervical cancer—cumulative pregnancy rate in a series of 123 women. BJOG 2006; 113: 719-24.
  68. Bernardini M, Barrett J, Seaward G, Covens A. Pregnancy outcomes in patients after radical trachelectomy. Am J Obstet Gynecol 2003; 189: 1378-82.
  69. Burnett AF, Roman LD, O’Meara AT, Morrow CP. Radical vaginal trachelectomy and pelvic lymphadenectomy for preser-vation of fertility in early cervical carcinoma. Gynecol Oncol 2003; 88: 419-23.
  70. Schlaerth JB, Spirtos NM, Schlaerth AC. Radical trachelectomy and pelvic lymphadenectomy with uterine preservation in the treatment of cervical cancer. Am J Obstet Gynecol 2003; 188: 29-34.
  71. Dargent D, Martin X, Sacchetoni A, Mathevet P. Laparoscopic vaginal radical trachelectomy: a treatment to preserve the fertility of cervical carcinoma patients. Cancer 2000; 88: 1877-82.
  72. Ayhan A, Tohma YA, Sahin H, Kocaman E, Tunc M, Haberal AN. Oncological and obstetric outcomes after fertility-sparing radical abdominal trachelectomy for early-stage cervical cancer: a tertiary centre’s 10 years’ experience. J Obstet Gynaecol 2019; 39: 248-52.
  73. Kasuga Y, Nishio H, Miyakoshi K, Sato S, Sugiyama J, Matsumoto T, et al. Pregnancy outcomes after abdominal radical trachelectomy for early-stage cervical cancer: a 13-year experience in a single tertiary-care center. Int J Gynecol Cancer 2016; 26: 163-8.
  74. Tamauchi S, Kajiyama H, Sakata J, Sekiya R, Suzuki S, Mizuno M, et al. Oncologic and obstetric outcomes of early stage cervical cancer with abdominal radical trachelectomy: single-institution experience. J Obstet Gynaecol Res 2016; 42: 1796-801.
  75. Tokunaga H, Watanabe Y, Niikura H, Nagase S, Toyoshima M, Shiro R, et al. Outcomes of abdominal radical trachelecto-my: results of a multi.center prospective cohort study in a Tohoku gynecologic cancer unit. Int J Clin Oncol 2015; 20: 776-80.
  76. Vieira MA, Rendon GJ, Munsell M, Echeverri L, Frumovitz M, Schmeler KM, et al. Radical trachelectomy in early-stage cervical cancer: a comparison of laparotomy and minimally invasive surgery. Gynecol Oncol 2015; 138: 585-9.
  77. Capilna ME, Ioanid N, Scripcariu V, Gavrilescu MM, Szabo B. Abdominal radical trachelectomy: a Romanian series. Int J Gynecol Cancer 2014; 24: 615-9.
  78. Kucukmetin A, Biliatis I, Ratnavelu N, Patel A, Cameron I, Ralte A, Naik R. Laparoscopic radical trachelectomy is an alter-native to laparotomy with improved perioperative outcomes in patients with early-stage cervical cancer. Int J Gynecol Cancer 2014; 24: 135-40.
  79. Van Gent MD, van den Haak LW, Gaarenstroom KN, Peters AA, van Poelgeest MI, Trimbos JB, de Kroon CD. Nerve-sparing radical abdominal trachelectomy versus nerve-sparing radical hysterectomy in early-stage (FIGO IA2-IB) cervical cancer: a comparative study on feasibility and outcome. Int J Gynecol Cancer 2014; 24: 735-43.
  80. Nishio H, Fujii T, Sugiyama J, Kuji N, Tanaka M, Hamatani T, et al. Reproductive and obstetric outcomes after radical ab-dominal trachelectomy for early-stage cervical cancer in a series of 31 pregnancies. Hum Reprod 2013; 28: 1793-8.
  81. Testa R, Ramirez PT, Ferreyra H, Saadi J, Franco G, Goldsman M, Perrotta M. Abdominal radical trachelectomy: a safe and feasible option for fertility preservation in developing countries. J Low Genit Tract Dis 2013; 17: 378-84.
  82. Muraji M, Sudo T, Nakagawa E, Ueno S, Wakahashi S, Kanayama S, et al. Type II versus type III fertility-sparing abdominal radical trachelectomy for early-stage cervical cancer: a comparison of feasibility of surgical outcomes. Int J Gynecol Cancer 2012; 22: 479-83.
  83. Nick AM, Frumovitz MM, Soliman P, Schmeler KM, Ramierz PT. Fertility sparing surgery for treatment of early-stage cervi-cal cancer: open vs. robotic radical trachelectomy. Gynecol Oncol 2012; 124: 276-80.
  84. Pareja FR, Ramirez PT, Borrero FM, Angel CG. Abdominal radical trachelectomy for invasive cervical cancer: a case series and literature review. Gynecol Oncol 2008; 111: 555-60.
  85. Saso S, Ghaem-Maghami S, Chatterjee J, Naji O, Farthing A, Mason P, et al. Abdominal radical trachelectomy in West London. BJOG 2012; 119: 187-93.
  86. Wethington SL, Cibula D, Duska LR, Garrett L, Kim CH, Chi DS, et al. An international series on abdominal radical tra-chelectomy: 101 patients and 28 pregnancies. Int J Gynecol Cancer 2012; 22: 1251-7.
  87. Du XL, Sheng XG, Jiang T, Li QS, Yu H, Pan CX, et al. Sentinel lymph node biopsy as guidance for radical trachelectomy in young patients with early stage cervical cancer. BMC Cancer 2011; 11: 157.
  88. Li J, Li Z, Wang H, Zang R, Zhou Y, Ju X, et al. Radical abdominal trachelectomy for cervical malignancies: surgical, oncolog-ical and fertility outcomes in 62 patients. Gynecol Oncol 2011; 121: 565-70.
  89. Yao T, Mo S, Lin Z. The functional reconstruction of fertility-sparing radical abdominal trachelectomy for early stage cervi-cal carcinoma. Eur J Obstet Gynecol Reprod Biol 2010; 151: 77-81.
  90. Olawaiye A, Del Carmen M, Tambouret R, Goodman A, Fuller A, Duska LR. Abdominal radical trachelectomy: success and pitfalls in a general gynecology and oncology practice. Gynecol Oncol 2009; 112: 506-10.
  91. Ungár L, Pálfalvi L, Hogg R, Siklos P, Boyle DCM, Del Priore G, Smith JR. Abdominal radical trachelectomy: a fertility-preserving option for women with early cervical cancer. BJOG 2005; 112: 366-9.
  92. Rodriguez M, Guimares O, Rose P. Radical abdominal trachelectomy and pelvic lymphadenectomy with uterine conserva-tion and subsequent pregnancy in the treatment of early invasive cervical cancer. Am J Obstet Gynecol 2001; 185: 370-4.
  93. Johansen G, Lönnerfors C, Falconer H, Persson J. Reproductive and oncologic outcome following robot-assisted laparoscopic radical trachelectomy for early-stage cervical cancer. Gynecol Oncol 2016; 141: 160-5.
  94. Ebisawa K, Takano M, Fukuda M, Fujiwara K, Hada T, Ota Y, et al. Obstetric outcomes of patients undergoing total laparo-scopic radical trachelectomy for early-stage cervical cancer. Gynecol Oncol 2013; 131: 83-6.
  95. Lu Q, Zhang Y, Liu C, Wang S, Guo S, Zhang Z. Total laparoscopic radical trachelectomy in the treatment of early squamous cell cervical cancer: a retrospective study with 8-year follow-up. Gynecol Oncol 2013; 130: 275-9.
  96. Martin A, Torrent A. Laparoscopic nerve-sparing radical trachelectomy:surgical technique and outcome. J Minim Invasive Gynecol 2010; 17: 37-41.
  97. Burnett AF, Stone PJ, Duckworth LA, Roman JJ. Robotic radical trachelectomy for preservation of fertility in early cervical cancer: case series and description of technique. J Minim Invasive Gynecol 2009; 16: 569-72.
  98. Park NY, Chong GO, Cho YL, Park IS, Lee YS. Total laparoscopic nervesparing radical trachelectomy. J Laparoendosc Adv Surg Tech A 2009; 19: 53-8.
  99. Jolley JA, Battista L, Wing DA. Management of pregnancy after radical trachelectomy: case reports and systematic review of the literature. Am J Perinatol 2007; 24: 531-9.
  100. Donnez J. CO2 laser laparoscopy in infertile women with endometriosis and women with adnexal adhesions. Fertil Steril 1987; 48: 390-4.
  101. Tang J, Li J, Wang S, Zhang D, Wu X. On what scale does it benefit the patients if uterine arteries were preserved during ART? Gynecol Oncol 2014; 134: 154-9.
  102. Muraji M, Sudo T, Iwasaki S, Ueno S, Wakahashi S, Yamaguchi S, et al. The effect of abdominal radical trachelectomy on ovarian reserve: serial changes in serum anti-mullerian hormone levels. J Cancer 2012; 3: 191-5.
  103. Chawanpaiboon S, Vogel JP, Moller AB, Lumbiganon P, Petzold M, Hogan D, et al. Global, regional, and national estimates of levels of preterm birth in 2014: a systematic review and modelling analysis. Lancet Glob Health 2019; 7: e37-46.
  104. Takada S, Ishioka S, Endo T, Baba T, Morishita M, Akashi Y, et al. Difficulty in the management of pregnancy after vaginal radical trachelectomy. Int J Clin Oncol 2013; 18: 1085-90.
  105. Kasuga Y, Miyakoshi K, Nishio H, Akiba Y, Otani T, Fukutake M, et al. Mid-trimester residual cervical length and the risk of preterm birth in pregnancies after abdominal radical trachelectomy: a retrospective analysis. BJOG 2017; 124: 1729-35.
  106. Alvarez RM, Biliatis I, Rockall A, Papadakou E, Sohaib SA, deSouza NM, et al. MRI measurement of residual cervical length after radical trachelectomy for cervical cancer and the risk of adverse pregnancy outcomes: a blinded imaging analysis. BJOG 2018; 125: 1726-33.
  107. Noyes N, Abu-Rustum NR, Ramirez PT, Plante M. Options in the management of fertility-related issues after radical tra-chelectomy in patients with early cervical cancer. Gynecol Oncol 2009; 114: 117-20.
  108. Ma LK, Cao DY, Yang JX, Liu JT, Shen K, Lang JH. Pregnancy outcome and obstetric management after vaginal radical tra-chelectomy. Eur Rev Med Pharmacol Sci 2014; 18: 3019-24.
  109. Campos APC, Geber GP, Hurtado R, Sampaio M, Geber S. Ovarian response after random-start controlled ovarian stimula-tion to cryopreservation oocytes in cancer patients. JBRA Assist Reprod 2018; 22: 352-4.
  110. Ayhan A, Tohma YA, Sahin H, Kocaman E, Tunc M, Haberal AN. Oncological and obstetric outcomes after fertility-sparing radical abdominal trachelectomy for early-stage cervical cancer: a tertiary centre’s 10 years’ experience. J Obstet Gynaecol 2019; 39: 248-52.
  111. Li X, Xia L, Li J, Chen X, Ju X, Wu X. Reproductive and obstetric outcomes after abdominal radical trachelectomy (ART) for patients with early-stage cervical cancers in Fudan, China. Gynecol Oncol 2020; 157: 418-22.
  112. Iwata T, Machida H, Matsuo K, Okugawa K, Saito T, Tanaka K, et al. The validity of the subsequent pregnancy index score for fertility-sparing trachelectomy in early-stage cervical cancer. Fertil Steril 2021; 115: 1250-8.
Advanced Search

Article Tools

About Journal

Forms

Social Media

Congress Calender

Reviewer's Corner

Author's Corner

Useful Links

Subscribe
Scopus
Pubmed Central
Latest Update: 06.03.2024
2024 © Galenos Publishing House.