Original Investigation

Spontaneous and IVF pregnancies have comparable first trimester screening profiles for Down syndrome


  • Yılmaz Güzel
  • Engin Türkgeldi
  • Hande Yağmur
  • Zeki Salar
  • Başak Balaban
  • Bülent Urman
  • Özgür Öktem

Received Date: 09.05.2018 Accepted Date: 10.09.2018 J Turk Ger Gynecol Assoc 0;0(0):0-0 [e-Pub] PMID: 30206047


We aimed to compare the first trimester screening profiles of spontaneous (n=972) and IVF pregnancies (n=339) in a population of patients who had uncomplicated singleton pregnancies comparable for maternal age, gestation, BMI, and ethnicity.

Material and Methods:

A non-interventional analysis of retrospective cohort data and review of the literature.


All IVF pregnancies were achieved via ICSI using the same ovarian stimulation protocol with recombinant FSH and a GnRH antagonist, cetrorelix acetate. The means of the multiple of median (MoM) of PAPP-A were slightly lower in the fresh (1.19±0.6 vs. 1.33±0.7, respectively; p=0.056) and frozen ET (1.03±0.5 vs. 1.33±0. 7, respectively; p=0.036) IVF pregnancies compared with natural conceptions. However, when the medians of the MoMs of PAPP-A and β-hCG, and their distributions were compared across the mode of conception, there were no differences between IVF pregnancies spontaneous pregnancies. Furthermore, the scatterplot diagram and curve fitting regression analyses revealed no difference in the temporal relations of β-hCG and PAPP-A with each other and gestational age between spontaneous and IVF pregnancies.


These results support the notion that uncomplicated singleton IVF pregnancies have similar first trimester screening profiles to spontaneous conceptions.

Keywords: First trimester screening,PAPP-A,β-hCG,NT,Pregnancy,IVF,ICSI