Prolonged PPROM may be catastrophic both for the mother and fetus due to ascending infections. The decision was expectant management in the setting of a spontaneous preterm premature rupture of membranes (PPROM) case and the prevention of chorioamnionitis was essential. We aimed to describe maternal and neonatal outcomes in expectant management of PPROM beginning from the 24th gestational week (GW) of pregnancy up to the 34th week under treatment with continuous usage of intravaginal clindamycin cream. We concluded that expectant active management of PPROM with antibiotics may be a suitable treatment option in carefully selected patients after receiving the patient’s approval. Intravaginal clindamycin cream may be combined with systemic antibiotics (ampicillin and erythromycin) and may be a maintenance single drug for the prophylaxis of ascending vaginal infections.

Keywords: PPROM, Clindamycin vaginal cream, chorioamninitis