Review

Polycystic ovarian syndrome: Environmental/occupational, life style factors-an overview

10.4274/jtgga.galenos.2019.2018.0142

  • Chaoba Kshetrimayum
  • Anupama Sharma
  • V. V. Mishra
  • Sunil Kumar

J Turk Ger Gynecol Assoc 0;0(0):0-0 [e-Pub] PMID: 30821135

PCOS is a multifaceted disease in women with infertility that have diverse etiological factors. Some women may have only a few PCOS linked symptoms or mild symptoms while some of the women will have severe or all PCOS linked symptoms. Therefore, the PCOS symptoms can differ among the woman. PCOS is a state of hormonal imbalance, excess terminal hair (hirsutism), hair loss (alopecia), menstruation impairments, metabolic disorders and cysts appearance on the ovaries. The cysts hamper ovulation, thus reducing the ability of women to become pregnant and resulted into infertility.

The data available suggests that PCOS might be originated in utero and phenotypic appearance of PCOS symptoms may be developed at later life which could be linked with host factors (endogenous and exogenous), lifestyle, and dietary, environmental or occupational factors etc.

Based upon the available information, it can be postulated that prenatal exposure to excessive androgen might be responsible for androgenization of the fetus which in turn may alter the program of differentiating target tissues and the phenotypic characters of PCOS can be persuaded by exposure of female child to various endogenous and exogenous factors at later life. Genetic/host and environmental/lifestyle factors might be related to the pathophysiology of PCOS after prenatal exposure to androgen. Additional studies are necessary to understand the exact mechanism responsible for the manifestation of PCOS as it is a very important issue in female reproduction.

Keywords: PCOS,Environmental,Occupational,Hyperandrogenism,Anovulation,Genetic factors,Androgenization,Infertility