Case Report

Overdistended duplicated bladder and sudden fetal demise after inadverdent exposure to long-acting gonadotropin-releasing hormone agonist in early pregnancy

  • Nupur Gupta
  • Shikha Sarangi
  • Deepika Deka
  • Suneeta Mittal

J Turk Ger Gynecol Assoc 2009;10(1):55-56


Gonadotropin-releasing hormone agonists are being increasingly used in infertility and gynaecological practice for treatment of fibroids, endometriosis and in vitro fertilization cycles.


A 24-year-old nulliparous lady with a fibroid uterus had an inadvertent exposure to two doses of leuprolide acetate and conceived spontaneously while awaiting hysteroscopic myomectomy. The fetus suffered anomalies of urogenital system and sudden intrauterine fetal demise at 31 weeks gestation.


Till date, no consensus has been gathered on the management of gonadotropin-releasing hormone agonist exposed pregnancies, risk of teratogenecity and perinatal outcome.

Keywords: Gonadototropin-releasing hormone agonist, congenital anomaly, fetal outcome