Original Investigation

Iodine deficiency in pregnant women at first trimester in Ankara

10.4274/jtgga.2017.0150

  • Kazibe Koyuncu
  • Batuhan Turgay
  • Feride Söylemez

Received Date: 02.01.2018 Accepted Date: 23.04.2018 J Turk Ger Gynecol Assoc 0;0(0):0-0 [e-Pub] PMID: 29699957

Objective:

Iodine deficiency in pregnant woman in Ankara was shown in previous studies. We aimed to conduct a study in a tertiary center to investigate for the need for iodine replacement in our population

Material and Methods:

This was a single tertiary center, non-interventional, retrospective, cross-sectional study. Data were retrieved retrospectively from 440 women who had been in first trimester in gestational age. Maternal iodine status, TSH levels, T4 levels were examined. Urinary iodine concentration (UIC) was calculated based on Sandell-Kolthoff reaction which is a colorimetric method. We excluded patients with previous thyroid disease or current thyroid disease. Thyroid hormones and TSH were measured by chemiluminescence immunoassays.

Results:

Iodine deficiency prevalence (UI <150 μg/L) was 84.7 % in first trimester of pregnancy in our population. The median UIC was 81.6 (1-450) μg/L, indicating iodine insufficiency. All the patients declared iodized salt use. None of the patients were taking iodine replacement. The mean TSH level was 1.53±1.27 mIU/l, (0.01 mIU/l-14.74 mIU/l) and mean T4 levels was 12.51±5.01 mIU/l, (7.09 mIU/l, -23.7 mIU/l). TSH levels of 56 patients were higher than 2.5 mIU/l. According to these results 12.72% of the patients had subclinical hypothyroidism based on serum TSH and Free T4 levels. Isolated hypothyroxinemia was present in one patient.

Conclusion:

Our study demonstrated that pregnant women still suffer from iodine deficiency in Ankara despite of mandatory iodine salt use. Iodized salt use does not provide enough iodine supplement especially in pregnant women. Iodine supplementation is shown to enhance neurological development and psychomotor performance. We suggest that iodine should be a part of routine laboratory evaluation at the first prenatal visit for its importance in early pregnancy. Also, iodized salt use education should be provided to the women to eradicate iodine deficiency. Iodine supplements should be recommended to all pregnant women in addition to iodized salt.

Keywords: Iodine deficiency,pregnancy