Original Investigation

Metabolic and carbohydrate characteristics of different phenotypes of polycystic ovary syndrome

10.5152/jtgga.2016.16133

  • Ebru Çelik
  • Ilgin Türkçüoglu
  • Baris Ata
  • Abdullah Karaer
  • Pinar Kirici
  • Sevil Eraslan
  • Çagatay Taskapan
  • Bülent Berker

Received Date: 01.08.2016 Accepted Date: 27.10.2016 J Turk Ger Gynecol Assoc 2016;17(4):201-208 PMID: 27990089

Objective:

To compare the prevalence of various metabolic and cardiovascular risk factors and insulin resistance between polycystic ovary syndrome (PCOS) patients with or without hyperandrogenism.

Material and Methods:

This is a retrospective cross-sectional study involving women with PCOS as diagnosed according to the Androgen Excess (AE) Society definition (n=504) and women with normoandrogenemic PCOS (n=183). Anthropometrics, lipid profile, glucose, insulin, oral glucose tolerance test (OGTT), and reproductive hormone levels were evaluated.

Results:

Women with PCOS diagnosed according to the AE Society had a significantly higher prevalence of metabolic syndrome compared with the normoandrogenemic PCOS phenotype: odds ratio (OR) 2.95 [95% confidence interval (CI) 1.21–7.21]. There was no significant difference in the prevalence glucose intolerance test between the groups [OR: 2.15, 95% CI 0.71–6.56]. The prevalence of low high density lipoprotein (HDL)-cholesterol in the group under the AE-PCOS Society criteria was higher than that of the normoandrogenemic PCOS group [OR: 2.82, 95%CI 1.29–3.36].

Conclusion:

The risks of metabolic syndrome and cardiovascular disease may vary among the phenotypes of PCOS based on the Rotterdam criteria. This new data may be of reference in informing women with PCOS, although further prospective studies are needed to validate this proposition.

Keywords: Polycystic ovary syndrome, diagnostic categories, metabolic syndrome, hyperanderogenism, insulin resistance