Original Investigation

Maternal serum and urinary carbohydrate antigen 19-9 as a marker in pregnancies with antenatal hydronephrosis: a preliminary and descriptive study

10.4274/jtgga.galenos.2019.2019.0101

  • Murat Akbaş
  • Faik Mümtaz Koyuncu
  • Burcu Artunç Ülkümen
  • Fatma Taneli
  • Habib Özdemir

Received Date: 11.06.2019 Accepted Date: 22.09.2019 J Turk Ger Gynecol Assoc 0;0(0):0-0 [e-Pub] PMID: 31564081

Objective:

Fetal hydronephrosis (FH) is the most common fetal renal pathology encountered in the daily obstetric practice. Urinary and serum carbohydrate antigen 19-9 (CA 19-9) levels are higher in obstructive renal pathologies. Our aim was to assess the maternal urinary and serum CA 19-9 levels in pregnancies with FH and compare results with controls.

Materials and Methods:

20 pregnancies with severe FH, 20 pregnancies with mild-moderate FH, and 20 healthy singleton pregnancies were included in this descriptive, case-control study. Maternal urinary and serum CA19-9 level were measured and compared between groups.

Results:

Severe FH cases had significantly higher maternal urinary CA19-9 level compared to control group (Median = 75 vs 24; respectively, U = 8.6, p = 0.014). The difference between mild-moderate FH and control group was not statistically significant in terms of urinary CA 19-9 level. No statistically significant difference was found between the groups with respect to the maternal serum CA 19-9 levels.

Conclusion:

Our results show that maternal urinary CA 19-9 level is significantly higher in the pregnancies with severe FH but serum CA 19-9 levels were not different between groups. If the mechanisms of transplacental passage and maternal urinary excretion are clarified, maternal urinary CA 19-9 may be a potential marker for pointing fetal kidney damage.

Keywords: hydronephrosis,pregnancy,CA-19-9 antigen