MATERIAL-METHOD:

Thirty-four cervical specimens, in which 17cases were previously diagnosed as normal cervix and 17 cases were low-grade SILs, included in the study. Ki-67 immunohistochemical staining was performed using avidin biotin complex.

RESULTS:

After reevaluating the cases by means of histo-pathological and Ki-67 immunostaining features, 21 of 34 cases were diagnosed as normal cervix and 13 were diagnosed as low-grade SILs. Ki-67 index was higher in low-grade SILs (p<0.05). Although Ki-67 positive cell clusters was not observed in normal cervix, 77% of 13 low-grade SILs had positive cell clusters (p<0.05).

CONCLUSIONS:

Ki-67 immunostaining may be considered as an easy and reproducible technique in differential diagnosis of normal cervix and low-grade SIL.

Keywords: Cervix, Ki-67, immunohistochemistry, low-grade squamous intraepithelial lesion