Clinical Study

Evaluation of Ki-67 Immunostaining in the Differential Diagnosis of Low Grade Squamous Intraepithelial Lesion and Normal Cervix

  • Sema Dilek Arici
  • Gonca Imir
  • Hatice Özer
  • Sahande Elagöz
  • Gülay Simsek
  • Meral Çetin

Received Date: 27.02.2007 Accepted Date: 29.05.2007 J Turk Ger Gynecol Assoc 2007;8(3):285-289


Thirty-four cervical specimens, in which 17cases were previously diagnosed as normal cervix and 17 cases were low-grade SILs, included in the study. Ki-67 immunohistochemical staining was performed using avidin biotin complex.


After reevaluating the cases by means of histo-pathological and Ki-67 immunostaining features, 21 of 34 cases were diagnosed as normal cervix and 13 were diagnosed as low-grade SILs. Ki-67 index was higher in low-grade SILs (p<0.05). Although Ki-67 positive cell clusters was not observed in normal cervix, 77% of 13 low-grade SILs had positive cell clusters (p<0.05).


Ki-67 immunostaining may be considered as an easy and reproducible technique in differential diagnosis of normal cervix and low-grade SIL.

Keywords: Cervix, Ki-67, immunohistochemistry, low-grade squamous intraepithelial lesion