Original Investigation

Effects of drospirenone pill in Indian women with polycystic ovary syndrome.


  • Sudhindra Mohan Bhattacharya
  • Mainak Ghosh
  • Nupur Gupta

Received Date: 25.04.2011 Accepted Date: 29.06.2011 J Turk Ger Gynecol Assoc 2011;12(3):144-147 PMID: 24591981


To study the effects of treatment of a drospirenone pill (DRSP) (with ethinyl oestradiol, EE) in Indian women with polycystic ovary syndrome (PCOS).


51 women with PCOS (Androgen excess society criteria, 2006),with preset inclusion-exclusion criteria, treated with a combination of EE 30 mcg and DRSP 3 mg cyclically in the traditional (21+7) regimen, were evaluated at baseline and after six and twelve cycles of treatment. Parameters studied were - body mass index (BMI), abdominal circumference (AC), Ferriman Galwey (FG) score, presence of acne and acanthosis nigricans, serum testosterone, sex hormone binding globulin (SHBG), fasting glucose and fasting insulin levels. Free Androgen Index (FAI) and Glucose: insulin ratio (G: I) were calculated.


Significant improvements in clinical and biochemical hyperandrogenic parameters were found at the two points of study. There were no significant changes in BMI, AC, incidence of acanthosis, metabolic parameters studied.


EE/DRSP improves hyperandrogenic parameters significantly without affecting the insulin resistance adversely in Indian women with PCOS.

Keywords: Drospirenone pill, polycystic ovary syndrome, androgenic parameters, insulin resistance, Indian women