Original Investigation

Does Aquaporin-1 expression have clinical significance in serous epithelial ovarian cancer?


  • Mustafa Kemal Takal
  • Cem Baykal
  • Eralp Başer
  • Mustafa Derda Kaya
  • Polat Dursun
  • Özlem Özen
  • Asuman Nihan Haberal
  • Ali Ayhan

Received Date: 15.03.2013 Accepted Date: 16.05.2013 J Turk Ger Gynecol Assoc 2013;14(3):130-135 PMID: 24592091


To assess the relationship between Aquaporin-1 (AQP1) expression and clinicopathological variables in serous epithelial ovarian cancer (EOC).

Material and Methods:

Serous EOC cases treated in our institution between January 2007 and December 2009 were included in the study. A semi-quantitative immunohistochemical method was used to determine AQP1 expression levels, intratumoral microvessel density (IMD) and AQP1/IMD ratios. The relationship between these parameters and clinicopathological variables were assessed. P values less than 0.05 was considered statistically significant.


A total of 55 cases of serous EOC were included in the study. AQP1 was strongly expressed in the membranes of microvessels and small vessels within all tumor tissues. In a few cases, AQP1 expression was also observed in the membrane of interstitial cells and in individual tumor cells. A positive correlation was detected between preoperative CA125 levels and the expression of AQP1 (R: 0.277, p<0.05). AQP1 expression was similar between FIGO stage I-II and FIGO stage III-IV cases (p > 0.05). A significant relationship did not exist between AQP1 expression and FIGO stage, lymph node metastasis or ascites volume (p>0.05).


In this study, AQP1 expression did not have a significant association with important clinicopathological variables in serous EOC. Future studies are needed to determine AQP1 expression in other histological types of EOC.

Keywords: Aquaporin-1, intratumoral microvessel density, serous epithelial ovarian cancer