Original Investigation

Comparison of serum androgens and endometrial thickness in obese and non-obese postmenopausal women


  • Ilker Inan Arikan
  • Aykut Barut
  • Deniz Arikan
  • Müge Harma
  • Mehmet I. Harma
  • Serpil Bozkurt

Received Date: 03.08.2010 Accepted Date: 13.11.2010 J Turk Ger Gynecol Assoc 2010;11(3):149-151 PMID: 24591922


In this study, we investigated whether serum androgen levels and endometrial thickness differed in obese and non-obese women.

Material and Methods:

Thirtytwo non-obese (BMI <30) and 48 obese (BMI ≥ 30) women were enrolled. Blood samples were analyzed for testosterone, free testosterone, androstenedione, DHEAS, and SHBG, and transvaginal ultrasonography was performed.


Obese women had significantly higher free testosterone and endometrial thickness and significantly lower SHBG. Eight of 17 women with endometrial thickness >5 mm had significant pathology.


These results suggest that obesity may be a risk factor for endometrial carcinoma and other pathologies in post-menopausal women through an action on androgen concentrations.

Keywords: Serum androgene, endometrial thickness, obesity, postmenopause