Original Investigation

C-reactive protein and lipoprotein-a as markers of coronary heart disease in polycystic ovary syndrome


  • Nilgün Güdücü
  • Herman İşçi
  • Alin Başgül Yiğiter
  • İlkkan Dünder

Received Date: 09.05.2012 Accepted Date: 12.11.2012 J Turk Ger Gynecol Assoc 2012;13(4):227-232 PMID: 24592047


The aim of this study was to investigate the risk factors of coronary heart disease, CRP and Lipoprotein-a in polycystic ovary syndrome patients.

Material and Methods:

Prospectively collected data of polycystic ovary syndrome patients (n=62) and control group (n=40) were compared.


PCOS patients had higher HOMA-IR, CRP, DHEAS, free testosterone, FAI, LH and prolactin levels when compared to the control group. Lipoprotein-a levels did not differ between the groups. The obese PCOS group had statistically significantly higher fasting blood glucose, total cholesterol, triglyceride, free testosterone, insulin, CRP and HOMA-IR and statistically significantly lower HDL and SHBG when compared to normal weight PCOS persons. Fasting blood glucose, total cholesterol, LDL, SHBG, CRP, Lipoprotein-a, FSH, LH, TSH, DHEAS and prolactin levels did not differ between the normal weight and obese control groups.


CRP levels increase in polycystic ovary syndrome patients and can be used as a marker of coronary heart disease. Future studies can be directed at treatments to decrease CRP levels, including antiinflammatory treatments.

Keywords: Polycystic ovary syndrome, obesity, CRP, lipoprotein-a, coronary heart disease