Original Investigation

Association between fok1 polymorphism of vitamin D receptor gene with uterine leiomyoma in Turkish populations


  • Seda Güleç Yılmaz
  • Tuğçe Gül
  • Rukset Attar
  • Gazi Yıldırım
  • Turgay İşbir

Received Date: 03.01.2018 Accepted Date: 29.01.2018 J Turk Ger Gynecol Assoc 0;0(0):0-0 [e-Pub] PMID: 29391329


The aim of this research was to determine the association between the fok1 polymorphism and uterine leiomyomas.

Material and Methods

For genotyping the fok1 polymorphism of vitamin D receptor, real-time polymerase chain reaction was performed on blood samples of uterine leiomyoma (n=27) and control (n=33) groups. For statistical analyses, SPSS v.23 software (SPSS Inc., Chicago, IL, USA) was used.


A statistically significant difference was observed for the frequency of the CC genotype between the uterine leiomyoma and control groups and, the frequencies of the T allele in uterine leiomyoma groups were significantly higher than the control group.


The presence of the fok1 CC genotype may be a risk-reducing factor and the T allele may be a potential risk factor for developing uterine leiomyoma.

Keywords: Vitamin D Receptor,Polymorphism,fok1,uterine leiomyoma