Original Investigation

Assessment of early decline in the percentage of ß-hCG values between days 0 and 4 after methotrexate therapy in ectopic pregnancy for the prediction of treatment success


  • Ebru Çelik
  • Ilgin Türkçüoglu
  • Abdullah Karaer
  • Pinar Kirici
  • Sevil Eraslan

Received Date: 08.03.2013 Accepted Date: 26.05.2013 J Turk Ger Gynecol Assoc 2013;14(3):125-129 PMID: 24592090


To evaluate percentage changes in serum beta-human chorionic gonadotropin (β-hCG) values between days 0-1, 0-4 and 0-7 as an indicator of methotrexate therapy success in extra-uterine pregnancies.

Material and Methods:

Women with ectopic pregnancy treated with single-dose methotrexate therapy between January 2011 and August 2012 were assessed. Recorded data were reviewed electronically from patient files. All women (n=93) with an ectopic pregnancy treated medically with intramuscular methotrexate (50 mg/m2) were included. The percentage changes in serum β-hCG levels from day 0 to 1, day 0 to 4 and day 0 to 7 were calculated for each case.


The median β-hCG values decreased between days 0 and 4 by 55.8%, and 89.6% of these cases were treatment successes. The median initial serum β-hCG values were lower in women with successful treatment, but this was not statistically significant (p=0.11).


A decline in serum β-hCG values between days 0 and 4 appears to be the best predictor. It would be beneficial to determine whether a woman with an ectopic pregnancy treated with single-dose methotrexate administration will be treated successfully.

Keywords: Ectopic pregnancy, human chorionic gonadotrophin, methotrexate.